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Csrp3 Gene Detail
Summary
  • Symbol
    Csrp3
  • Name
    cysteine and glycine-rich protein 3
  • Synonyms
    CRP3, MLP, muscle LIM protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330824
    NCBI Gene: 13009
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:48480146-48497781 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 31.11 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    690 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330824
 protein coding gene Chr7:48480146-48497799 (-)
129S1/SvImJ ENSMUSG00200025631
 protein coding gene Chr7:36106361-36123998 (-)
A/J ENSMUSG00195048251
 protein coding gene Chr7:40110655-40128290 (-)
AKR/J ENSMUSG00220008226
 protein coding gene Chr7:34400500-34418130 (-)
BALB/cJ ENSMUSG00180028443
 protein coding gene Chr7:36994380-37012016 (-)
C3H/HeJ ENSMUSG00175036885
 protein coding gene Chr7:37567830-37585475 (-)
C57BL/6NJ ENSMUSG00215041009
 protein coding gene Chr7:36777352-36794995 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029785
 protein coding gene Chr7:51917241-51935243 (-)
CAST/EiJ ENSTCUG00005022249
 protein coding gene Chr7:40598095-40615874 (-)
CBA/J ENSMUSG00210040098
 protein coding gene Chr7:37879002-37896645 (-)
DBA/2J ENSMUSG00185028217
 protein coding gene Chr7:41777369-41795001 (-)
FVB/NJ ENSMUSG00205028435
 protein coding gene Chr7:37524947-37542586 (-)
JF1/MsJ ENSUMUG00000051404
 protein coding gene Chr7:46525558-46543493 (-)
LP/J ENSMUSG00230049574
 protein coding gene Chr7:47292811-47310682 (-)
NOD/ShiLtJ ENSMUSG00190049490
 protein coding gene Chr7:37865786-37883415 (-)
NZO/HlLtJ ENSMUSG00225013702
 protein coding gene Chr7:45404765-45422404 (-)
PWK/PhJ ENSLUMG00010038701
 protein coding gene Chr7:36636149-36653847 (-)
SPRET/EiJ ENSMSPG00010040307
 protein coding gene Chr7:36475491-36493453 (-)
WSB/EiJ ENSIUOG00005027200
 protein coding gene Chr7:38217105-38234747 (-)



Homology
more
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSRP3, cysteine and glycine rich protein 3
  • Synonyms
    CLP, CMD1M, CMH12, CRP3, MLP
  • Links
    NCBI Gene ID: 8048
    UniProt: P50461

  • Chr Location
    11p15.1; chr11:19176519-19210571 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with Csrp3 mouse models; 4 with human CSRP3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit dilated cardiomyopathy characterized by disrupted cardiomyocyte organization that results in premature death, left ventricle dilation, hypertrophy, decreased contractility, and fibrosis. Some homozygotes die postnataly due to heart failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    86
  • cDNA Data
    11
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030470 Ensembl Gene Model | MGI Sequence Detail 17636 C57BL/6J ±  kb
    transcript ENSMUST00000167786 Ensembl | MGI Sequence Detail 899 Not Applicable  
    polypeptide ENSMUSP00000129378 Ensembl | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 13
      Primer pair 5
      Other 3
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 19
      Diseases 4
      Gene Ontology 14
      Phenotypes 54
    • Earliest
      J:33993 Harrod GV, et al., Murine MLP: cloning and expression in the embryonic head. J Craniofac Genet Dev Biol. 1996 Apr-Jun;16(2):65-73
    • Latest
      J:375445 Elmore G, et al., RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure. Cardiovasc Res. 2025 Nov 22;121(14):2204-2221
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory