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Targeted Allele Detail
Symbol: Csrp3tm1Crni
Name: cysteine and glycine-rich protein 3; targeted mutation 1, Pico Caroni
MGI ID: MGI:1858015
Synonyms: MLP-
Gene: Csrp3  Location: Chr7:48480146-48497781 bp, - strand  Genetic Position: Chr7, 31.11 cM, cytoband B3
Alliance: Csrp3tm1Crni page
Germline Transmission:  Earliest citation of germline transmission: J:38213
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exon 2. Northern blot analysis on RNA derived from heart of homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts derived from heart tissue confirmed that no stable protein was made from this allele. (J:38213)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csrp3 Mutation:  10 strains or lines available
Original:  J:38213 Arber S, et al., MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell. 1997 Feb 7;88(3):393-403
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory