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Mesp2 Gene Detail
Summary
  • Symbol
    Mesp2
  • Name
    mesoderm posterior 2
  • Synonyms
    bHLHc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096325
    NCBI Gene: 17293
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
  • Regulated by
    Rr441 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr7:79460475-79463179 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096325
 protein coding gene Chr7:79460475-79463187 (+)
129S1/SvImJ ENSMUSG00200030232
 protein coding gene Chr7:66274164-66276876 (+)
A/J ENSMUSG00195013187
 protein coding gene Chr7:70689017-70691729 (+)
AKR/J ENSMUSG00220037433
 protein coding gene Chr7:64231038-64233750 (+)
BALB/cJ ENSMUSG00180012290
 protein coding gene Chr7:67414145-67416857 (+)
C3H/HeJ ENSMUSG00175021168
 protein coding gene Chr7:68186238-68188950 (+)
C57BL/6NJ ENSMUSG00215016074
 protein coding gene Chr7:67285358-67288071 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029888
 protein coding gene Chr7:82363591-82366314 (+)
CAST/EiJ ENSTCUG00005041476
 protein coding gene Chr7:70738139-70740850 (+)
CBA/J ENSMUSG00210023904
 protein coding gene Chr7:68037506-68040218 (+)
DBA/2J ENSMUSG00185040794
 protein coding gene Chr7:72360251-72362963 (+)
FVB/NJ ENSMUSG00205019657
 protein coding gene Chr7:67926802-67929514 (+)
JF1/MsJ ENSUMUG00000020128
 protein coding gene Chr7:77020252-77022975 (+)
LP/J ENSMUSG00230011447
 protein coding gene Chr7:78449833-78452545 (+)
NOD/ShiLtJ ENSMUSG00190016635
 protein coding gene Chr7:68178751-68181463 (+)
NZO/HlLtJ ENSMUSG00225041962
 protein coding gene Chr7:76691472-76694184 (+)
PWK/PhJ ENSLUMG00010016169
 protein coding gene Chr7:66614845-66617556 (+)
SPRET/EiJ ENSMSPG00010020441
 protein coding gene Chr7:67025540-67027696 (+)
WSB/EiJ ENSIUOG00005019340
 protein coding gene Chr7:68526942-68529654 (+)



Homology
more
  • Human Ortholog
    MESP2, mesoderm posterior bHLH transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MESP2, mesoderm posterior bHLH transcription factor 2
  • Synonyms
    bHLHc6, SCDO2
  • Links
    NCBI Gene ID: 145873
    UniProt: Q0VG99

  • Chr Location
    15q26.1; chr15:89760591-89778754 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mesp2 mouse models; 1 with human MESP2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 11 alleles in 7 genetic backgrounds
    25 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit absence of segmented somites, fused vertebral columns and dorsal root ganglia, and impaired sclerotomal polarity. Mutants die shortly after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    923
  • Tissues
    121
  • cDNA Data
    16
  • Literature Summary
    93
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17293 NCBI Gene Model | MGI Sequence Detail 2705 C57BL/6J ±  kb
    transcript NM_008589 RefSeq | MGI Sequence Detail 1936 ZRU/MplStud  
    polypeptide O08574 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 16
      Primer pair 4
      Other 15
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 93
      Diseases 1
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:357898 Feng X, et al., Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2310283121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory