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Esr2 Gene Detail
Summary
  • Symbol
    Esr2
  • Name
    estrogen receptor 2 (beta)
  • Synonyms
    ER beta, ERbeta, Estrb, oestrogen receptor beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109392
    NCBI Gene: 13983
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76167193-76224033 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.52 cM, cytoband D1-D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1816 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109392
 protein coding gene Chr12:76167193-76224033 (-)
129S1/SvImJ ENSMUSG00200031269
 protein coding gene Chr12:68112435-68169190 (-)
A/J ENSMUSG00195014011
 protein coding gene Chr12:70824642-70881475 (-)
AKR/J ENSMUSG00220015029
 protein coding gene Chr12:68589848-68645424 (-)
BALB/cJ ENSMUSG00180032092
 protein coding gene Chr12:69785607-69842449 (-)
C3H/HeJ ENSMUSG00175034904
 protein coding gene Chr12:72944347-73001174 (-)
C57BL/6NJ ENSMUSG00215017972
 protein coding gene Chr12:69163737-69220587 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017859
 protein coding gene Chr12:70668350-70721855 (-)
CAST/EiJ ENSTCUG00005034693
 protein coding gene Chr12:69142861-69200581 (-)
CBA/J ENSMUSG00210028179
 protein coding gene Chr12:69371802-69428632 (-)
DBA/2J ENSMUSG00185039492
 protein coding gene Chr12:71242901-71298453 (-)
FVB/NJ ENSMUSG00205024522
 protein coding gene Chr12:69000683-69057444 (-)
JF1/MsJ ENSUMUG00000018239
 protein coding gene Chr12:75278576-75340751 (-)
LP/J ENSMUSG00230020903
 protein coding gene Chr12:78236187-78292944 (-)
NOD/ShiLtJ ENSMUSG00190010402
 protein coding gene Chr12:68422896-68479659 (-)
NZO/HlLtJ ENSMUSG00225036698
 protein coding gene Chr12:80298063-80354834 (-)
PWK/PhJ ENSLUMG00010027923
 protein coding gene Chr12:69309043-69364620 (-)
SPRET/EiJ ENSMSPG00010024717
 protein coding gene Chr12:71080605-71136189 (-)
WSB/EiJ ENSIUOG00005012227
 protein coding gene Chr12:69057514-69120706 (-)



Homology
more
  • Human Ortholog
    ESR2, estrogen receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ESR2, estrogen receptor 2
  • Synonyms
    Erb, ER-BETA, ESRB, ESR-BETA, ESTRB, NR3A2, ODG8
  • Links
    NCBI Gene ID: 2100
    UniProt: Q92731

  • Chr Location
    14q23.2-q23.3; chr14:64084232-64338613 (-)  GRCh38
Human Diseases
more
  • Diseases
    17 with human ESR2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    145 phenotypes from 7 alleles in 10 genetic backgrounds
    73 phenotypes from multigenic genotypes
    1 images
    320 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neural, behavior, glucose homeostasis, sex-specific nociception, cardiac, and ion channel abnormalities and myeloproliferative disorders. Females are sterile/subfertile with granulosa cell defects; males show prostate hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    150
  • cDNA Data
    13
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13983 NCBI Gene Model | MGI Sequence Detail 56841 C57BL/6J ±  kb
    transcript NM_207707 RefSeq | MGI Sequence Detail 3362 C57BL/6  
    polypeptide O08537 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007205 estrogen receptor beta
      (term hierarchy)
    • InterPro Domains
      IPR028355 Estrogen receptor beta/gamma
      IPR021064 Estrogen receptor beta-like, N-terminal
      IPR024178 Estrogen receptor/oestrogen-related receptor
      IPR001723 Nuclear hormone receptor
      IPR050200 Nuclear hormone receptor family NR3 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    • GlyGen
      O08537 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 15
      Primer pair 10
      Other 5
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38437
    References
    more
    • Summaries
      All 495
      Developmental Gene Expression 44
      Gene Ontology 21
      Phenotypes 320
    • Earliest
      J:38765 Chang PW, et al., Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein. J Cell Biochem. 1997 Feb;64(2):217-24
    • Latest
      J:390499 Commodore S, et al., The role of estrogen receptors and house dust mite-induced DNA methylation in a mouse model. Am J Physiol Lung Cell Mol Physiol. 2026 Aug 1;331(2):L119-L143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory