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Sox17 Gene Detail
Summary
  • Symbol
    Sox17
  • Name
    SRY (sex determining region Y)-box 17
Location &
Maps
more
  • Sequence Map
    Chr1:4561154-4567577 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107543
 protein coding gene Chr1:4561154-4567624 (-)
129S1/SvImJ ENSMUSG00200001998
 protein coding gene Chr1:1982299-1988718 (-)
A/J ENSMUSG00195002578
 protein coding gene Chr1:1766246-1772677 (-)
AKR/J ENSMUSG00220003489
 protein coding gene Chr1:1869013-1875432 (-)
BALB/cJ ENSMUSG00180008896
 protein coding gene Chr1:1835984-1842415 (-)
C3H/HeJ ENSMUSG00175000092
 protein coding gene Chr1:1707310-1713730 (-)
C57BL/6NJ ENSMUSG00215004070
 protein coding gene Chr1:1747329-1753752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013921
 protein coding gene Chr1:1307477-1313908 (-)
CAST/EiJ ENSTCUG00005001952
 protein coding gene Chr1:2124320-2130745 (-)
CBA/J ENSMUSG00210001604
 protein coding gene Chr1:1631266-1637690 (-)
DBA/2J ENSMUSG00185004160
 protein coding gene Chr1:2681448-2687872 (-)
FVB/NJ ENSMUSG00205005121
 protein coding gene Chr1:1895498-1901929 (-)
JF1/MsJ ENSUMUG00000002517
 protein coding gene Chr1:1971641-1978091 (-)
LP/J ENSMUSG00230002326
 protein coding gene Chr1:2682665-2689088 (-)
NOD/ShiLtJ ENSMUSG00190001204
 protein coding gene Chr1:1765007-1771438 (-)
NZO/HlLtJ ENSMUSG00225000073
 protein coding gene Chr1:6040420-6046847 (-)
PWK/PhJ ENSLUMG00010002217
 protein coding gene Chr1:1546534-1552973 (-)
SPRET/EiJ ENSMSPG00010013678
 protein coding gene Chr1:2029750-2035637 (-)
WSB/EiJ ENSIUOG00005010829
 protein coding gene Chr1:1770365-1776803 (-)



Homology
more
  • Human Ortholog
    SOX17, SRY-box transcription factor 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX17, SRY-box transcription factor 17
  • Synonyms
    PPH7, VUR3
  • Links
    NCBI Gene ID: 64321
    UniProt: Q9H6I2

  • Chr Location
    8q11.23; chr8:54457935-54460892 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Sox17 mouse models; 3 with human SOX17 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 8 alleles in 17 genetic backgrounds
    11 phenotypes from multigenic genotypes
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted null mutation develop a deficient gut endoderm and die around embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1214
  • Tissues
    298
  • cDNA Data
    40
  • Literature Summary
    197
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025902 Ensembl Gene Model | MGI Sequence Detail 6424 C57BL/6J ±  kb
    transcript ENSMUST00000027035 Ensembl | MGI Sequence Detail 3127 Not Applicable  
    polypeptide ENSMUSP00000027035 Ensembl | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 40
      Primer pair 8
      Other 5
      Antibodies 16

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36114
    References
    more
    • Summaries
      All 328
      Developmental Gene Expression 197
      Diseases 2
      Gene Ontology 33
      Phenotypes 97
    • Earliest
      J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
    • Latest
      J:378501 Zhu Q, et al., Distal enhancers regulate mammalian early embryonic lineage differentiation through long-range interactions. Nucleic Acids Res. 2026 Jan 14;54(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory