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Plcb4 Gene Detail
Summary
  • Symbol
    Plcb4
  • Name
    phospholipase C, beta 4
  • Synonyms
    A930039J07Rik, C230058B11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107464
    NCBI Gene: 18798
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:135500931-135856513 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 66.64 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9847 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107464
 protein coding gene Chr2:135500523-135856522 (+)
129S1/SvImJ ENSMUSG00200007400
 protein coding gene Chr2:132760125-132899470 (+)
A/J ENSMUSG00195015266
 protein coding gene Chr2:132809039-132948379 (+)
AKR/J ENSMUSG00220036357
 protein coding gene Chr2:132509952-132649208 (+)
BALB/cJ ENSMUSG00180027692
 protein coding gene Chr2:132625009-132764352 (+)
C3H/HeJ ENSMUSG00175030541
 protein coding gene Chr2:133154680-133294019 (+)
C57BL/6NJ ENSMUSG00215016056
 protein coding gene Chr2:132649528-132788866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024353
 protein coding gene Chr2:128296780-128649520 (+)
CAST/EiJ ENSTCUG00005010999
 protein coding gene Chr2:131888860-132027845 (+)
CBA/J ENSMUSG00210037385
 protein coding gene Chr2:133055708-133195046 (+)
DBA/2J ENSMUSG00185039833
 protein coding gene Chr2:132688572-132827659 (+)
FVB/NJ ENSMUSG00205020529
 protein coding gene Chr2:131820982-131960323 (+)
JF1/MsJ ENSUMUG00000022064
 protein coding gene Chr2:132466651-132614123 (+)
LP/J ENSMUSG00230007877
 protein coding gene Chr2:134386479-134525817 (+)
NOD/ShiLtJ ENSMUSG00190029274
 protein coding gene Chr2:132750297-132889624 (+)
NZO/HlLtJ ENSMUSG00225026599
 protein coding gene Chr2:142348398-142487499 (+)
PWK/PhJ ENSLUMG00010036050
 protein coding gene Chr2:132488134-132629418 (+)
SPRET/EiJ ENSMSPG00010026481
 protein coding gene Chr2:134778918-134987623 (+)
WSB/EiJ ENSIUOG00005023644
 protein coding gene Chr2:132533148-132679756 (+)



Homology
more
  • Human Ortholog
    PLCB4, phospholipase C beta 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCB4, phospholipase C beta 4
  • Synonyms
    ARCND2, ARCND2A, ARCND2B, PI-PLC
  • Links
    NCBI Gene ID: 5332
    UniProt: Q15147

  • Chr Location
    20p12.3-p12.2; chr20:9067825-9504593 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations may exhibit ataxia, impaired elimination of excess climbing fiber synapses in the developing cerebellum, abnormal cerebellar foliation, reduced visual processing ability and loss of circadian rhythm in constant darkness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    179
  • cDNA Data
    66
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039943 Ensembl Gene Model | MGI Sequence Detail 355583 C57BL/6J ±  kb
    transcript ENSMUST00000110109 Ensembl | MGI Sequence Detail 5217 Not Applicable  
    polypeptide ENSMUSP00000105736 Ensembl | MGI Sequence Detail 1175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • PDB
      6IRD
    • EC
      3.1.4.11
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR053945 Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR042531 Phospholipase C-beta, C-terminal domain superfamily
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    • GlyGen
      Q91UZ1 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-35936, MGI:1925078, MGI:2139106, MGI:2443533
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 8
      Phenotypes 69
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:385967 Chon U, et al., Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly. Curr Biol. 2026 May 8;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory