About   Help   FAQ
Coq7 Gene Detail
Summary
  • Symbol
    Coq7
  • Name
    demethyl-Q 7
  • Synonyms
    clk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107207
    NCBI Gene: 12850
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:118108881-118132529 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    962 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107207
 protein coding gene Chr7:118108881-118132579 (-)
129S1/SvImJ ENSMUSG00200021002
 protein coding gene Chr7:104614429-104638617 (-)
A/J ENSMUSG00195037784
 protein coding gene Chr7:109171352-109195084 (-)
AKR/J ENSMUSG00220020628
 protein coding gene Chr7:102603361-102627059 (-)
BALB/cJ ENSMUSG00180023897
 protein coding gene Chr7:105834644-105858368 (-)
C3H/HeJ ENSMUSG00175021528
 protein coding gene Chr7:106526915-106551101 (-)
C57BL/6NJ ENSMUSG00215040691
 protein coding gene Chr7:105774677-105798375 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030365
 protein coding gene Chr7:120687992-120712461 (-)
CAST/EiJ ENSTCUG00005037965
 protein coding gene Chr7:109112730-109136891 (-)
CBA/J ENSMUSG00210024273
 protein coding gene Chr7:106250296-106274486 (-)
DBA/2J ENSMUSG00185021515
 protein coding gene Chr7:110600856-110625064 (-)
FVB/NJ ENSMUSG00205018998
 protein coding gene Chr7:106236472-106260168 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230031423
 protein coding gene Chr7:116714701-116726765 (-)
NOD/ShiLtJ ENSMUSG00190020337
 protein coding gene Chr7:106454345-106478042 (-)
NZO/HlLtJ ENSMUSG00225037834
 protein coding gene Chr7:114980611-115004333 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010008828
 protein coding gene Chr7:106009693-106033952 (-)
WSB/EiJ ENSIUOG00005010352
 protein coding gene Chr7:107122561-107146218 (-)



Homology
more
  • Human Ortholog
    COQ7, coenzyme Q7, hydroxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COQ7, coenzyme Q7, hydroxylase
  • Synonyms
    CAT5, COQ10D8, HMNR9
  • Links
    NCBI Gene ID: 10229
    UniProt: Q99807

  • Chr Location
    16p12.3; chr16:19067614-19083097 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human COQ7 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 5 alleles in 7 genetic backgrounds
    1 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations in this gene are embryonic lethal during mid-gestation with aborted neurogenesis and abnormal mitochondria. Mice heterozygous for a null allele exhibit extended lifespan with mitochondrial dysfunction and altered inner and outer membrane ubiquinone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    107
  • cDNA Data
    37
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12850 NCBI Gene Model | MGI Sequence Detail 23649 C57BL/6J ±  kb
    transcript NM_001304758 RefSeq | MGI Sequence Detail 1221 C57BL/6  
    polypeptide P97478 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 39
      Primer pair 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35669
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 7
      Gene Ontology 21
      Phenotypes 24
    • Earliest
      J:33381 Jonassen T, et al., Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7. (Correction appears in Arch Biochem Biophys 1996; 335(1):227). Arch Biochem Biophys. 1996 Jun 15;330(2):285-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory