Sequence Detail

ID/Version

P97478 Q9R0D7 (UniProt | EBI)

Last sequence update: 1999-07-15
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial {ECO:0000305|PubMed:20923139}; EC=1.14.13.253 {ECO:0000269|PubMed:20923139};AltName: Full=3-demethoxyubiquinone 3-hydroxylase (NADH) {ECO:0000305|PubMed:20923139};Alt

Provider

SWISS-PROT

Sequence

Polypeptide 217 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Coq7	demethyl-Q 7	49	103	3	14

Sequence references in MGI

J:49821 Ewbank JJ, et al., Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1 [see comments]. Science. 1997 Feb 14;275(5302):980-3
J:56031 Asaumi S, et al., Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. Genomics. 1999 Jun 15;58(3):293-301
J:57837 Vajo Z, et al., Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. Mamm Genome. 1999 Oct;10(10):1000-4
J:152626 Lapointe J, et al., Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice. J Biol Chem. 2009 Jul 24;284(30):20364-74
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:383922 Behan RK, et al., The aging-associated enzyme CLK-1 is a member of the carboxylate-bridged diiron family of proteins. Biochemistry. 2010 Nov 16;49(45):9679-81
J:384311 Takahashi M, et al., Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans. Biochem Biophys Res Commun. 2001 Aug 24;286(3):534-40