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Slc18a1 Gene Detail
Summary
  • Symbol
    Slc18a1
  • Name
    solute carrier family 18 (vesicular monoamine), member 1
  • Synonyms
    4832416I10Rik, MGC:28683, MGC:37299
  • Feature Type
    protein coding gene
  • IDs
    MGI:106684
    NCBI Gene: 110877
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:69490363-69541887 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.88 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106684
 protein coding gene Chr8:69490360-69547951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033664
 protein coding gene Chr8:69182268-69236167 (-)
A/J MGP_AJ_G0033646
 protein coding gene Chr8:66386627-66441384 (-)
AKR/J MGP_AKRJ_G0033571
 protein coding gene Chr8:68210241-68267844 (-)
BALB/cJ MGP_BALBcJ_G0033642
 protein coding gene Chr8:66603203-66661204 (-)
C3H/HeJ MGP_C3HHeJ_G0033352
 protein coding gene Chr8:68931623-68983584 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034159
 protein coding gene Chr8:71791788-71848115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031106
 protein coding gene Chr8:61266180-61316891 (-)
CAST/EiJ MGP_CASTEiJ_G0032677
 protein coding gene Chr8:68383585-68436793 (-)
CBA/J MGP_CBAJ_G0033330
 protein coding gene Chr8:74473522-74525737 (-)
DBA/2J MGP_DBA2J_G0033484
 protein coding gene Chr8:66103422-66154841 (-)
FVB/NJ MGP_FVBNJ_G0033425
 protein coding gene Chr8:65258082-65306175 (-)
LP/J MGP_LPJ_G0033572
 protein coding gene Chr8:69290955-69368808 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033469
 protein coding gene Chr8:77132932-77187958 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034177
 protein coding gene Chr8:68477282-68529241 (-)
PWK/PhJ MGP_PWKPhJ_G0032386
 protein coding gene Chr8:65351570-65409917 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032222
 protein coding gene Chr8:67448806-67508112 (-)
WSB/EiJ MGP_WSBEiJ_G0032794
 protein coding gene Chr8:68856146-68910702 (-)



Homology
more
  • Human Ortholog
    SLC18A1, solute carrier family 18 member A1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC18A1, solute carrier family 18 member A1
  • Synonyms
    CGAT, VAT1, VMAT1
  • Links
    NCBI Gene ID: 6570
    neXtProt AC: NX_P54219
    UniProt: P54219

  • Chr Location
    8p21.3; chr8:20144855-20183206 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SLC18A1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased neuron apoptosis, decreased neuron proliferation and impaired spatial object recognition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    209
  • cDNA Data
    17
  • Literature Summary
    18
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036330 Ensembl Gene Model | MGI Sequence Detail 51525 C57BL/6J ±  kb
transcript ENSMUST00000037478 Ensembl | MGI Sequence Detail 3115 Not Applicable  
polypeptide ENSMUSP00000046924 Ensembl | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 18
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35143, MGI:2443911
References
more
  • Summaries
    All 53
    Developmental Gene Expression 18
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:16163 Peter D, et al., Chromosomal localization of the human vesicular amine transporter genes. Genomics. 1993 Dec;18(3):720-3
  • Latest
    J:330805 Sato DX, et al., Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. iScience. 2022 Aug 19;25(8):104800
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory