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Zic1 Gene Detail
Summary
  • Symbol
    Zic1
  • Name
    zinc finger protein of the cerebellum 1
  • Synonyms
    odd-paired homolog
Location &
Maps
more
  • Sequence Map
    Chr9:91240111-91247863 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 48.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    149 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106683
 protein coding gene Chr9:91240111-91250136 (-)
129S1/SvImJ ENSMUSG00200005181
 protein coding gene Chr9:88352478-88360241 (-)
A/J ENSMUSG00195006858
 protein coding gene Chr9:87619576-87627330 (-)
AKR/J ENSMUSG00220019137
 protein coding gene Chr9:88000551-88008308 (-)
BALB/cJ ENSMUSG00180007095
 protein coding gene Chr9:87946133-87953884 (-)
C3H/HeJ ENSMUSG00175004417
 protein coding gene Chr9:88257562-88265315 (-)
C57BL/6NJ ENSMUSG00215008408
 protein coding gene Chr9:88252110-88259874 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032520
 protein coding gene Chr9:87234428-87242181 (-)
CAST/EiJ ENSTCUG00005004078
 protein coding gene Chr9:88187476-88195230 (-)
CBA/J ENSMUSG00210005582
 protein coding gene Chr9:88120913-88128677 (-)
DBA/2J ENSMUSG00185001611
 protein coding gene Chr9:88295097-88302846 (-)
FVB/NJ ENSMUSG00205004508
 protein coding gene Chr9:88451246-88458991 (-)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190011144
 protein coding gene Chr9:87917192-87924945 (-)
NZO/HlLtJ ENSMUSG00225015674
 protein coding gene Chr9:88595929-88603674 (-)
PWK/PhJ ENSLUMG00010002897
 protein coding gene Chr9:88007900-88015633 (-)
SPRET/EiJ ENSMSPG00010002352
 protein coding gene Chr9:89697061-89704779 (-)
WSB/EiJ ENSIUOG00005003482
 protein coding gene Chr9:87346195-87353937 (-)



Homology
more
  • Human Ortholog
    ZIC1, Zic family zinc finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZIC1, Zic family zinc finger 1
  • Synonyms
    BAIDCS, CRS6, ZIC, ZNF201
  • Links
    NCBI Gene ID: 7545
    UniProt: Q15915

  • Chr Location
    3q24; chr3:147393422-147510293 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Zic1 mouse models; 2 with human ZIC1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 4 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show cerebellar hypoplasia with a missing lobule of the anterior lobe. Newborn pups suckle poorly. 50% die within one day of birth and almost all die within 3 weeks; longer survivors show marked ataxia and exhibit tonic convulsions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1089
  • Tissues
    204
  • cDNA Data
    26
  • Literature Summary
    120
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032368 Ensembl Gene Model | MGI Sequence Detail 7753 C57BL/6J ±  kb
    transcript ENSMUST00000034927 Ensembl | MGI Sequence Detail 5606 Not Applicable  
    polypeptide ENSMUSP00000034927 Ensembl | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 2
      cDNA 27
      Primer pair 14
      Other 8
      Antibodies 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35142
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 120
      Diseases 2
      Gene Ontology 19
      Phenotypes 23
    • Earliest
      J:31270 Aruga J, et al., A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
    • Latest
      J:377967 Roome RB, et al., Ontogeny of the spinal cord dorsal horn. Science. 2026 Jan 8;391(6781):eadx5781
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory