Phenotypes Associated with This Genotype

Genotype
MGI:3716303

• Allelic Composition: Zic1^tm1Jaru/Zic1⁺
• Genetic Background: B6.129S4-Zic1^tm1Jaru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:72342 )

• mutants exhibit reduced horizontal motor activity

muscle

hypotonia ( J:72342 )

• mutants perform worse in a wire-hanging test than wild-type, however maximal grip strength is normal, indicating that muscle tone, but not maximal muscle strength, is reduced

• mutants show a slight, but significant reduction in ability to remain on a stationary rod, however show no difference in the retention time on a rotating rod

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Joubert syndrome		DOID:0050777	OMIM:PS213300	J:72342