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St8sia2 Gene Detail
Summary
  • Symbol
    St8sia2
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Synonyms
    Siat8b, ST8SiaII
  • Feature Type
    protein coding gene
  • IDs
    MGI:106020
    NCBI Gene: 20450
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:73588867-73663408 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 42.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2312 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106020
 protein coding gene Chr7:73588867-73663438 (-)
129S1/SvImJ ENSMUSG00200011281
 protein coding gene Chr7:60354590-60429394 (-)
A/J ENSMUSG00195013787
 protein coding gene Chr7:64748806-64823615 (-)
AKR/J ENSMUSG00220019690
 protein coding gene Chr7:58295225-58370033 (-)
BALB/cJ ENSMUSG00180013194
 protein coding gene Chr7:61457894-61532701 (-)
C3H/HeJ ENSMUSG00175019986
 protein coding gene Chr7:62255670-62330468 (-)
C57BL/6NJ ENSMUSG00215013471
 protein coding gene Chr7:61389882-61464585 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029862
 protein coding gene Chr7:76450952-76525054 (-)
CAST/EiJ ENSTCUG00005003975
 protein coding gene Chr7:64885374-64960293 (-)
CBA/J ENSMUSG00210023921
 protein coding gene Chr7:62120776-62202031 (-)
DBA/2J ENSMUSG00185000928
 protein coding gene Chr7:66443507-66524765 (-)
FVB/NJ ENSMUSG00205021434
 protein coding gene Chr7:62103392-62178222 (-)
JF1/MsJ ENSUMUG00000023425
 protein coding gene Chr7:71174865-71249799 (-)
LP/J ENSMUSG00230013875
 protein coding gene Chr7:72491779-72566575 (-)
NOD/ShiLtJ ENSMUSG00190017908
 protein coding gene Chr7:62209511-62284304 (-)
NZO/HlLtJ ENSMUSG00225041379
 protein coding gene Chr7:70759593-70834382 (-)
PWK/PhJ ENSLUMG00010016552
 protein coding gene Chr7:60729181-60804157 (-)
SPRET/EiJ ENSMSPG00010020029
 protein coding gene Chr7:61155903-61227389 (-)
WSB/EiJ ENSIUOG00005021184
 protein coding gene Chr7:62590501-62671769 (-)



Homology
more
  • Human Ortholog
    ST8SIA2, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA2, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Synonyms
    HsT19690, SIAT8-B, SIAT8B, ST8SiaII, ST8SIA-II, STX
  • Links
    NCBI Gene ID: 8128
    UniProt: Q92186

  • Chr Location
    15q26.1; chr15:92393881-92468728 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal mossy fiber morphology, increased exploration in new environment and impaired fear responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    129
  • cDNA Data
    76
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20450 NCBI Gene Model | MGI Sequence Detail 74542 C57BL/6J ±  kb
    transcript NM_009181 RefSeq | MGI Sequence Detail 5354 C57BL/6  
    polypeptide O35696 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 4
      cDNA 76
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33702, MGI:2141905
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 11
      Gene Ontology 13
      Phenotypes 43
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:381822 Niculovic KM, et al., Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice. Angiogenesis. 2025 May 24;28(3):31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory