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Lair1 Gene Detail
Summary
  • Symbol
    Lair1
  • Name
    leukocyte-associated Ig-like receptor 1
  • Synonyms
    5133400O11Rik, D7Bwg0421e, Lair-1, mLair-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105492
    NCBI Gene: 52855
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4006401-4066178 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.31 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1100 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105492
 protein coding gene Chr7:4006401-4076566 (-)
129S1/SvImJ ENSMUSG00200037360
 protein coding gene Chr7:766498-826103 (-)
A/J ENSMUSG00195047053
 protein coding gene Chr7:717860-777472 (-)
AKR/J ENSMUSG00220023587
 protein coding gene Chr7:3317542-3385937 (+)
BALB/cJ ENSMUSG00180046321
 protein coding gene Chr7:685138-744746 (-)
C3H/HeJ ENSMUSG00175043826
 protein coding gene Chr7:677508-737112 (-)
C57BL/6NJ ENSMUSG00215043628
 protein coding gene Chr7:723914-783719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029103
 protein coding gene Chr7:707435-761845 (-)
CAST/EiJ ENSTCUG00005025818
 protein coding gene Chr7:929110-981407 (-)
CBA/J ENSMUSG00210044914
 protein coding gene Chr7:677443-737047 (-)
DBA/2J ENSMUSG00185037042
 protein coding gene Chr7:862905-922512 (-)
FVB/NJ ENSMUSG00205038030
 protein coding gene Chr7:681094-764026 (-)
JF1/MsJ ENSUMUG00000049082
 protein coding gene Chr7:971778-1020781 (-)
LP/J ENSMUSG00230033393
 protein coding gene Chr7:3884719-3944316 (-)
NOD/ShiLtJ ENSMUSG00190046337
 protein coding gene Chr7:749379-808985 (-)
NZO/HlLtJ ENSMUSG00225020319
 protein coding gene Chr7:1797437-1857033 (-)
PWK/PhJ ENSLUMG00010044379
 protein coding gene Chr7:4455401-4509008 (-)
SPRET/EiJ ENSMSPG00010048183
 protein coding gene Chr7:926943-982451 (-)
WSB/EiJ ENSIUOG00005050898
 protein coding gene Chr7:689476-749262 (-)



Homology
more
  • Human Ortholog
    LAIR1, leukocyte associated immunoglobulin like receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAIR1, leukocyte associated immunoglobulin like receptor 1
  • Synonyms
    CD305, LAIR-1
  • Links
    NCBI Gene ID: 3903
    UniProt: Q6GTX8

  • Chr Location
    19q13.42; chr19:54351384-54376088 (-)  GRCh38
  • Human Ortholog
    LAIR2, leukocyte associated immunoglobulin like receptor 2
  • Synonyms
    CD306
  • Links
    NCBI Gene ID: 3904
    UniProt: Q6ISS4

  • Chr Location
    19q13.42; chr19:54497879-54510687 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are healthy and of normal longevity but show increased numbers of splenic B, regulatory T, and dendritic cells, and eosinophilia at a young age. Aging homozygotes display a higher frequency of activated and effector/memory T cells and a decreased IgG1 level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055541 Ensembl Gene Model | MGI Sequence Detail 59778 C57BL/6J ±  kb
transcript ENSMUST00000086401 Ensembl | MGI Sequence Detail 2496 Not Applicable  
polypeptide ENSMUSP00000083589 Ensembl | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33164, MGI:1918474, MGI:2142289
References
more
  • Summaries
    All 50
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:44191 Kubagawa H, et al., A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells [see comments]. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5261-6
  • Latest
    J:385386 Dorando HK, et al., LAIR1 prevents excess inflammatory tissue damage in Staphylococcus aureus skin infection and Cutaneous T-cell Lymphoma. JCI Insight. 2025 Nov 13;11(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory