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Srxn1 Gene Detail
Summary
  • Symbol
    Srxn1
  • Name
    sulfiredoxin 1 homolog (S. cerevisiae)
  • Synonyms
    1700127B04Rik, Npn3, Srx, Srx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104971
    NCBI Gene: 76650
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151947436-151953296 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM, cytoband H1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    30
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104971
 protein coding gene Chr2:151946738-151953296 (+)
129S1/SvImJ ENSMUSG00200029000
 protein coding gene Chr2:148851688-148857355 (+)
129S1/SvImJ ENSMUSG00200028937
 protein coding gene Chr2:148856624-148860621 (+)
A/J ENSMUSG00195021313
 protein coding gene Chr2:149136601-149140600 (+)
A/J ENSMUSG00195021360
 protein coding gene Chr2:149131668-149137332 (+)
AKR/J ENSMUSG00220043006
 protein coding gene Chr2:148460134-148464132 (+)
AKR/J ENSMUSG00220043078
 protein coding gene Chr2:148455564-148460865 (+)
BALB/cJ ENSMUSG00180042666
 protein coding gene Chr2:148617059-148622363 (+)
BALB/cJ ENSMUSG00180042623
 protein coding gene Chr2:148621632-148625631 (+)
C3H/HeJ ENSMUSG00175037475
 protein coding gene Chr2:149362916-149368580 (+)
C3H/HeJ ENSMUSG00175037383
 protein coding gene Chr2:149367849-149371848 (+)
C57BL/6NJ ENSMUSG00215018096
 protein coding gene Chr2:148794843-148798842 (+)
C57BL/6NJ ENSMUSG00215018293
 protein coding gene Chr2:148789910-148795574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024446
 protein coding gene Chr2:143994511-144000164 (+)
CAST/EiJ ENSTCUG00005041805
 protein coding gene Chr2:147719742-147725047 (+)
CBA/J ENSMUSG00210043316
 protein coding gene Chr2:149304367-149308366 (+)
CBA/J ENSMUSG00210043454
 protein coding gene Chr2:149299795-149305098 (+)
DBA/2J ENSMUSG00185045593
 protein coding gene Chr2:148949946-148955610 (+)
DBA/2J ENSMUSG00185045543
 protein coding gene Chr2:148954879-148958877 (+)
FVB/NJ ENSMUSG00205020856
 protein coding gene Chr2:148051591-148055589 (+)
FVB/NJ ENSMUSG00205021044
 protein coding gene Chr2:148047019-148052322 (+)
JF1/MsJ ENSUMUG00000044982
 protein coding gene Chr2:148635855-148664541 (+)
LP/J ENSMUSG00230033515
 protein coding gene Chr2:150604128-150609795 (+)
LP/J ENSMUSG00230033450
 protein coding gene Chr2:150609064-150613060 (+)
NOD/ShiLtJ ENSMUSG00190029930
 protein coding gene Chr2:148735393-148764074 (+)
NZO/HlLtJ ENSMUSG00225003910
 protein coding gene Chr2:158643003-158647001 (+)
NZO/HlLtJ ENSMUSG00225003983
 protein coding gene Chr2:158638431-158643734 (+)
PWK/PhJ ENSLUMG00010040023
 protein coding gene Chr2:148605673-148632617 (+)
SPRET/EiJ ENSMSPG00010025541
 protein coding gene Chr2:151332134-151338331 (+)
WSB/EiJ ENSIUOG00005041962
 protein coding gene Chr2:148467568-148472873 (+)



Homology
more
  • Human Ortholog
    SRXN1, sulfiredoxin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRXN1, sulfiredoxin 1
  • Synonyms
    C20orf139, Npn3, SRX, SRX1
  • Links
    NCBI Gene ID: 140809
    UniProt: Q9BYN0

  • Chr Location
    20p13; chr20:646615-653378 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS-induced shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    2
  • cDNA Data
    56
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032802 Ensembl Gene Model | MGI Sequence Detail 5861 C57BL/6J ±  kb
    transcript ENSMUST00000041500 Ensembl | MGI Sequence Detail 2812 Not Applicable  
    polypeptide ENSMUSP00000046196 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 56
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-31044, MGI:1923900, MGI:2139100, MGI:2139350
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:327984 Rius-Perez S, et al., p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3. Redox Biol. 2022 Aug 20;56:102423
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory