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Nfkbib Gene Detail
Summary
  • Symbol
    Nfkbib
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
  • Synonyms
    IKappaBbeta, IkB
  • Feature Type
    protein coding gene
  • IDs
    MGI:104752
    NCBI Gene: 18036
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28457676-28466069 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.91 cM, cytoband A3-B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    329 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104752
 protein coding gene Chr7:28457676-28466937 (-)
129S1/SvImJ ENSMUSG00200041983
 protein coding gene Chr7:18246286-18255551 (-)
A/J ENSMUSG00195041921
 protein coding gene Chr7:20924438-20933670 (-)
AKR/J ENSMUSG00220051617
 protein coding gene Chr7:23559623-23568881 (+)
BALB/cJ ENSMUSG00180048822
 protein coding gene Chr7:18983994-18993226 (-)
C3H/HeJ ENSMUSG00175044204
 protein coding gene Chr7:20011946-20021207 (-)
C57BL/6NJ ENSMUSG00215052274
 protein coding gene Chr7:18147628-18156889 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029460
 protein coding gene Chr7:27966502-27975597 (-)
CAST/EiJ ENSTCUG00005049971
 protein coding gene Chr7:19951425-19960702 (-)
CBA/J ENSMUSG00210052129
 protein coding gene Chr7:19196535-19205798 (-)
DBA/2J ENSMUSG00185042748
 protein coding gene Chr7:22309271-22318532 (-)
FVB/NJ ENSMUSG00205034362
 protein coding gene Chr7:18990107-18999375 (-)
JF1/MsJ ENSUMUG00000041572
 protein coding gene Chr7:26717417-26726696 (-)
LP/J ENSMUSG00230052424
 protein coding gene Chr7:27479792-27489053 (-)
NOD/ShiLtJ ENSMUSG00190030636
 protein coding gene Chr7:18643556-18652819 (-)
NZO/HlLtJ ENSMUSG00225025660
 protein coding gene Chr7:26322909-26332172 (-)
PWK/PhJ ENSLUMG00010042043
 protein coding gene Chr7:18680565-18689777 (-)
SPRET/EiJ ENSMSPG00010047018
 protein coding gene Chr7:18034126-18042607 (-)
WSB/EiJ ENSIUOG00005052725
 protein coding gene Chr7:12913162-12922469 (-)



Homology
more
  • Human Ortholog
    NFKBIB, NFKB inhibitor beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFKBIB, NFKB inhibitor beta
  • Synonyms
    IKBB, TRIP9
  • Links
    NCBI Gene ID: 4793
    UniProt: Q15653

  • Chr Location
    19q13.2; chr19:38899666-38908893 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit decreased susceptibility to endotoxin shock and induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    694
  • Tissues
    34
  • cDNA Data
    7
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18036 NCBI Gene Model | MGI Sequence Detail 8394 C57BL/6J ±  kb
    transcript NM_010908 RefSeq | MGI Sequence Detail 2065 C57BL/6  
    polypeptide Q60778 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Other 1
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28043
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:23294 Thompson JE, et al., I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell. 1995 Feb 24;80(4):573-82
    • Latest
      J:371518 Chia JJ, et al., Distinct roles for NF-kappaB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging. Cell Rep. 2025 Aug 26;44(9):116193
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory