Nfkbib Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
MGI:104752

18 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nfkbib^tm1.2Rsch/Nfkbib^tm1.2Rsch B6.129P2-Nfkbib^tm1.2Rsch	abnormal cytokine secretion	J:176877
	abnormal immune system morphology	J:176877
	abnormal immune system physiology	J:176877
	abnormal interleukin-1 beta secretion	J:176877
	abnormal interleukin-6 secretion	J:176877
	abnormal tumor necrosis factor secretion	J:176877
	decreased B cell number	J:176877
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:176877
	increased macrophage cell number	J:176877
	increased marginal zone B cell number	J:176877
	increased memory T cell number	J:176877
Nfkbib^tm1Bal/Nfkbib^tm1Bal B6.129S1-Nfkbib^tm1Bal	decreased circulating interleukin-1 beta level	J:163302
	decreased circulating interleukin-6 level	J:163302
	decreased circulating tumor necrosis factor level	J:163302
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:163302
	decreased susceptibility to endotoxin shock	J:163302
	decreased susceptibility to induced arthritis	J:163302
	decreased tumor necrosis factor secretion	J:163302
Nfkbib^tm1Jpmz/Nfkbib^tm1Jpmz involves: 129/Sv * C57BL/6	no abnormal phenotype detected	J:113618

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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