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Nrl Gene Detail
Summary
  • Symbol
    Nrl
  • Name
    neural retina leucine zipper gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:102567
    NCBI Gene: 18185
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55756973-55762438 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102567
 protein coding gene Chr14:55756435-55762438 (-)
129S1/SvImJ ENSMUSG00200041393
 protein coding gene Chr14:44343923-44349927 (-)
A/J ENSMUSG00195032007
 protein coding gene Chr14:44560820-44566823 (-)
AKR/J ENSMUSG00220023723
 protein coding gene Chr14:43888726-43894729 (-)
BALB/cJ ENSMUSG00180048819
 protein coding gene Chr14:44184562-44190565 (-)
C3H/HeJ ENSMUSG00175042008
 protein coding gene Chr14:45866913-45872916 (-)
C57BL/6NJ ENSMUSG00215045682
 protein coding gene Chr14:44079628-44085632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019294
 protein coding gene Chr14:46941725-46947621 (-)
CAST/EiJ ENSTCUG00005046846
 protein coding gene Chr14:45862349-45868378 (-)
CBA/J ENSMUSG00210035632
 protein coding gene Chr14:44547353-44553356 (-)
DBA/2J ENSMUSG00185052879
 protein coding gene Chr14:49614768-49620773 (-)
FVB/NJ ENSMUSG00205028420
 protein coding gene Chr14:43957907-43963930 (-)
JF1/MsJ ENSUMUG00000039659
 protein coding gene Chr14:60847378-60853507 (-)
LP/J ENSMUSG00230052117
 protein coding gene Chr14:61709773-61715777 (-)
NOD/ShiLtJ ENSMUSG00190039575
 protein coding gene Chr14:44321290-44327313 (-)
NZO/HlLtJ ENSMUSG00225043959
 protein coding gene Chr14:52000365-52006368 (-)
PWK/PhJ ENSLUMG00010041602
 protein coding gene Chr14:43770090-43776099 (-)
SPRET/EiJ ENSMSPG00010042847
 protein coding gene Chr14:47177770-47182863 (-)
WSB/EiJ ENSIUOG00005037314
 protein coding gene Chr14:43762067-43768095 (-)



Homology
more
  • Human Ortholog
    NRL, neural retina leucine zipper
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRL, neural retina leucine zipper
  • Synonyms
    D14S46E, ESCS2, NRL-MAF, RP27
  • Links
    NCBI Gene ID: 4901
    UniProt: P54845

  • Chr Location
    14q11.2-q12; chr14:24078662-24115010 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nrl mouse models; 3 with human NRL associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    4 images
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a retinal defect causing loss of rod function, exaggerated cone function, short, sparse outer segments, and abnormal disks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    694
  • Tissues
    27
  • cDNA Data
    51
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18185 NCBI Gene Model | MGI Sequence Detail 5466 C57BL/6J ±  kb
    transcript NM_001271916 RefSeq | MGI Sequence Detail 1966 C57BL/6  
    polypeptide P54846 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011432 neural retina-specific leucine zipper protein
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR004826 Basic leucine zipper domain, Maf-type
      IPR046347 Basic-leucine zipper domain superfamily
      IPR013592 Maf transcription factor, N-terminal
      IPR024874 Transcription factor Maf family
      IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 53
      Primer pair 7
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19449, MGD-MRK-3718, MGI:2145817
    References
    more
    • Summaries
      All 209
      Developmental Gene Expression 36
      Diseases 3
      Gene Ontology 10
      Phenotypes 134
    • Earliest
      J:19401 Swaroop A, et al., A conserved retina-specific gene encodes a basic motif/leucine zipper domain. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):266-70
    • Latest
      J:378933 Boulan B, et al., Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. Sci Adv. 2026 Feb 6;12(6):eadz6827
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory