B6(Cg)-Psen2<tm2.1(PSEN2*N141I)Mdk> Isr(HSA19;APOE_i4)2Mdk Isr(HSA17;MAPT*N279K)4Mdk Psen1<tm4.1(PSEN1*V272A)Mdk> App<tm1.1(APP)Mdk>/J Strain Detail MGI Mouse MGI:8318878

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B6(Cg)-Psen2^{tm2.1(PSEN2*N141I)Mdk} Isr(HSA19;APOE_i4)2Mdk Isr(HSA17;MAPT*N279K)4Mdk Psen1^{tm4.1(PSEN1*V272A)Mdk} App^{tm1.1(APP)Mdk}/J Strain Detail

Summary

Strain Name

B6(Cg)-Psen2^{tm2.1(PSEN2*N141I)Mdk} Isr(HSA19;APOE_i4)2Mdk Isr(HSA17;MAPT*N279K)4Mdk Psen1^{tm4.1(PSEN1*V272A)Mdk} App^{tm1.1(APP)Mdk}/J
Attributes

chromosome aberration, mutant strain, targeted mutation
MGI ID

MGI:8318878
Synonyms

C57BL/6-Psen2^{tm2.1(PSEN2*N141I)Mdk} Isr(HSA19;APOE_i4)2Mdk Isr(HSA17;MAPT*N279K)4Mdk Psen1^{tm4.1(PSEN1*V272A)Mdk} App^{tm1.1(APP)Mdk}/J

Other IDs

JAX:040827

5 associated mutations

Mutation Carried	Marker
App^{tm1.1(APP)Mdk}	App
Isr(HSA17;MAPT*N279K)4Mdk	Isr(HSA17;MAPT*N279K)4Mdk
Isr(HSA19;APOE_i4)2Mdk	Isr(HSA19;APOE_i4)2Mdk
Psen1^{tm4.1(PSEN1*V272A)Mdk}	Psen1
Psen2^{tm2.1(PSEN2*N141I)Mdk}	Psen2

1 associated strain record at IMSR

IMSR	Repository	IMSR Strain	Why Matched
JAX:040827	JAX	B6(Cg)-Psen2^{tm2.1(PSEN2N141I)Mdk} Isr(HSA19;APOE_i4)2Mdk Isr(HSA17;MAPTN279K)4Mdk Psen1^{tm4.1(PSEN1*V272A)Mdk} App^{tm1.1(APP)Mdk}/J	exact match to ID

Earliest

J:347607 Benzow K, et al., Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice. Alzheimers Dement. 2024 Apr;20(4):3080-3087
All

1

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