App^{tm1.1(APP)Mdk}
Targeted Allele Detail

Summary

• Symbol: App^{tm1.1(APP)Mdk}
• Name: amyloid beta precursor protein; targeted mutation 1.1, Michael D Koob
• MGI ID: MGI:7565473
• Synonyms: APP-GR
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^{tm1.1(APP)Mdk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• App^{tm1.1(APP)Mdk} involves 1 genes/genome features (App) View all
• App^{tm1.1(APP)Mdk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The targeting vector is designed to insert a 343 kb (Chr21:25880264 - 26224036) fragment of the human APP (apolipoprotein) in place of 268 kb (Chr16:84750107 - 85019011) of the mouse App gene. The construct includes an FRT-flanked neomycin selection cassette. In addition, there is also a APP-DT (non-coding antisense RNA) in the human genome segment. The insertion disrupts App transcription.The neomycin cassette was removed by transient expression of cre. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 89 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)