Tc(HSA19*APOE_i4)1Mdk
Targeted Allele Detail

Summary

• Symbol: Tc(HSA19*APOE_i4)1Mdk
• Name: transchromosomal, human 19, line 1, Michael Koob; transchromosomal, human 19, line 1, Michael D Koob
• MGI ID: MGI:7565468
• Synonyms: APOE4-GR
• Gene: Tc(HSA19*APOE_i4)1Mdk Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tc(HSA19*APOE_i4)1Mdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:347607
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion
• Tc(HSA19*APOE_i4)1Mdk involves 4 genes/genome features (Apoc2, Apoc4, Apoc1 ...) View all
• Tc(HSA19*APOE_i4)1Mdk expresses 4 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOC1 (341)

  Apoc1

  (MGI:88053)

  human

  APOC2 (344)

  Apoc2	(MGI:88054)
  Apoc2l	(MGI:5753381)

  human

  APOC4 (346)

  Apoc4

  (MGI:87878)

  human

  APOE (348)

  Apoe	(MGI:88057)

  isoform 4

• Mutation details: A 30 kb deletion on mouse chromosome 7 stretching from, Apoe to Apoc is replaced by a syntenic 47 kb region from human chromosome 19 (HSA19). The mouse Apoe (apoliprotein e) isoform 4 and Apoc (apolipoprotein C) genes are replaced by human APOE (isoform E4) and APOC genes. A loxP-flanked neomycin resistance cassette is included in the construct. The neomycin cassette was removed by transient expression of cre. (J:101977, J:347607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tc(HSA19*APOE_i4)1Mdk Mutation: 1 strain or line available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)