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| May 16, 2013 |
- MGI is pleased to announce a new implementation of comparative genome data. Previously we used a one-to-one orthology relationship between a mouse gene and that of another mammalian species. MGI now uses homology class data from HomoloGene and supports a "many-to-many" relationship between mouse genes and their vertebrate homologs. Chicken, zebrafish and rhesus macaque homologs are now included in this release as well as human, chimpanzee, dog, cattle and rat.
- Vertebrate Homology Class pages include genetic location and links to EntrezGene, Comparative GO Graphs, sequences and HomoloGene multiple sequence alignments. For an example, see this complement component Vertebrate Homology Class page.
- Redesigned MGI Human Disease and Mouse Model Detail pages support the new homology class data and link to vertebrate homology class pages and mouse model phenotype data. For an example, see this Systemic Lupus Erythematosus Human Disease and Mouse Model Detail page.
- With this release, references now link to curated Gene Ontology (GO) functional annotations, in addition to genome features, phenotypic alleles and expression literature curation. For an example, see this reference summary page.
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| March 15, 2013 |
- MouseMine represents a new generation of access to MGI data. Powered by InterMine, MouseMine offers flexible querying, numerous predefined query templates, a point-and-click interface for building your own queries or modifying a template, iterative refinement of results, built-in enrichment analysis, downloading in multiple formats, forwarding to Galaxy, linking to other model organism Mines, and more.
- MouseMine:
- currently contains genetic, genomic and annotation data (function,
phenotype, disease) from MGI
- offers many useful "canned" queries, plus point-and-click query editing
- supports links to any object's detail page or to any query results page
- allows any query result to be downloaded (text, xml, json) or
forwarded to Galaxy
- supports uploading and manipulating lists of objects
- provides web service access to all of the above functions
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| January 31, 2013 |
- MGI now integrates phenotype data from high-throughput phenotyping centers with curated data from scientific publications, providing comprehensive comparative phenotypes for mouse mutants. Current data sets include those from the Wellcome Trust Sanger Institute (WTSI) and the Europhenome (EuPh) data. This integration allows specific comparisons between different Center data interpretations and is a model for future MGI data integration from the International Mouse Phenotyping Consortium (IMPC). All data on the MGI website are refreshed weekly.
- MGI Allele Summary Pages have been streamlined, concatinating biological systems where phenotypes have been detected while removing the details of each genotype examined. In addition, Allele Detail pages have been redesigned for clarity and performance, and to display results from these high-throughput phenotyping centers. Sex-specific phenotype data also are easier to discover.
- For an example, see this MGI Allele Detail page.
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Analysis Tools