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MGI News
January 5, 2023
MGI is now supporting the more secure HTTPS protocol.
Hypertext Transfer Protocol Secure (HTTPS) adds a Secure Sockets Layer (SSL) to HTTP. This encrypts exchanges between your browser and the MGI web server and reduces the risk of a malicious entity intercepting your web interactions.
Some web browsers by default are set to only use HTTPS and in order to access MGI, you had to turn off that preference. With this update, you have one less reason to turn that off.
MouseMine has already been using HTTPS for about a year. The International Mouse Strain Resource (IMSR) and the Mouse Models of Human Cancer Database (MMHCdb) will be using HTTPS in future releases.
December 15, 2022
The Global Biodata Coalition (GBC) designated MGD a Global Core Biodata Resource.
GCBR_Logo
Global Core Biodata Resources are biodata resources that are of fundamental importance to the wider biological and life sciences community and the long term preservation of biological data. They:
  • provide free and open access to their data,
  • are used extensively both in terms of the number and distribution of their users,
  • are mature and comprehensive,
  • are considered authoritative in their field,
  • are of high scientific quality, and
  • provide a professional standard of service delivery.
Their operation is based on well-established life-cycle management processes and well-understood dependencies with related data resources. GCBRs have either terms of use or specific licenses that conform to the Open Definition, to enable the reuse of data.
November 14, 2022
GXD introduces an Expression Profile Search.
  • GXD has developed the Expression Profile Search, a tool to search for genes by their expression profile. It allows users to define the expression profile of interest by specifying up to 10 anatomical structures and whether expression is present or absent in these structures. It can be found as a tab on the Gene Expression Data Query.
August 8, 2022
Human gene to disease annotations are now from the Alliance of Genome Resources.
  • MGI is now getting its human gene to disease associations from the Alliance of Genome Resources Homo sapiens associations disease file. This includes annotations from OMIM, Rat Genome Database (RGD), NCBI curation, Gene Reviews, and Gene Tests. The new sources included in the RGD curation pipeline increase the number of human gene to disease associations significantly.
June 27, 2022
This release provides additional recombinase (cre) enhancements:
  • We added non-mouse drivers to the Recombinase Activity Comparison Matrix. The Recombinase Activity Comparison Matrix allows you to compare endogenous wild-type gene expression with reported recombinase activity data (See an example).
  • The recombinase activity section on allele detail pages was also updated. For an example, see the Chatm2(cre)Lowl allele.
  • Both the Comparison Matrix and Detail page's grids display more experimental data and refined mouse ages.
April 25, 2022
This release features an enhanced Recombinase (cre) structure profile search, plus representations of the Ensembl Regulatory Build for mouse and mouse enhancer elements from the VISTA Enhancer Browser.
  • You can now search for Recombinase (cre) Activity in multiple structures.
  • Ensembl Regulatory features and VISTA enhancers are accessible on the Genes and Markers Query Form by selecting the desired feature type (expand other feature type/other genome feature to show all subcategories).
  • Four new feature types were added to accommodate Regulatory Features from Ensembl:
    • Promoter flanking region
    • CTCF binding site
    • Transcription factor binding site
    • Open chromatin region
  • You can also search for regulatory features by ID in the Quick Search
February 14, 2022
The highlight of this release is an all new Quick Search tool featuring:
  • Tabbed results for Genome Features, Alleles, Vocabulary Terms, Strains and Stocks, and IDs.
  • Depending on the tab, results can be filtered by feature type, GO terms, expression, and phenotype and disease annotations.
  • Strains and Stock results include links to the International Mouse Strain Resource (IMSR) and associated references.
  • You can search with genome coordinates for mouse or human (human coordinates return the mouse homologs of the human genes within the designated human coordinates).
  • Genome Feature and Alleles tabbed results can be forwarded to the MGI Batch Query or MouseMine. Genome Feature results can also be forwarded to the GXD Batch Query.
  • An "exact phrase" text search option is provided that returns only results with an exact match to the query string.
  • All results can be downloaded as text and spreadsheet files.
We fixed a bug in the Human - Mouse: Disease Connection
You can once again search with mouse or human genome coordinates.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory