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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wnt1
wingless-type MMTV integration site family, member 1
MGI:98953
55 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chek1tm1Sje/Chek1+
Tg(Wnt1)1Hev/0
Not Specified 		increased mammary adenocarcinoma incidence J:62919
Esr1tm1Ksk/Esr1tm1Ksk
Tg(Wnt1)1Hev/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal mammary gland development J:54215
increased mammary adenocarcinoma incidence J:54215
increased tumor latency J:54215
mammary gland alveolar hyperplasia J:54215
mammary gland duct hyperplasia J:54215
mammary gland hyperplasia J:54215
Gins4tm1Ntak/Gins4+
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		decreased tumor growth/size J:209708
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Wnt9btm1.1Amc/Wnt9btm1.1Amc
involves: 129X1/SvJ * C57BL/6 * CBA 		normal renal/urinary system phenotype J:100575
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Wnt9btm1.1Amc/Wnt9btm1.1Amc
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal kidney collecting duct morphology J:100575
abnormal kidney development J:100575
abnormal Mullerian duct morphology J:100575
neonatal lethality J:100575
Gt(ROSA)26Sortm2(Wnt1/GFP)Amc/Gt(ROSA)26Sor+
Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Tg(Tcfap2a-cre)1Will/0
involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ 		normal craniofacial phenotype J:178316
Hmga1tm1Mina/Hmga1tm1Mina
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
involves: C3H * C57BL/6 * CBA 		increased stomach tumor incidence J:153058
Id2tm1Yyk/Id2+
Tg(Wnt1)1Hev/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL 		abnormal branching of the mammary ductal tree J:96305
increased mammary gland tumor incidence J:96305
mammary gland hyperplasia J:96305
Id2tm1Yyk/Id2tm1Yyk
Tg(Wnt1)1Hev/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL 		abnormal branching of the mammary ductal tree J:96305
increased mammary gland tumor incidence J:96305
mammary gland hyperplasia J:96305
MtdhGt(XB780)Byg/Mtdh+
Tg(Wnt1)1Hev/0
FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev 		decreased mammary gland tumor incidence J:214244
increased tumor latency J:214244
MtdhGt(XB780)Byg/MtdhGt(XB780)Byg
Tg(Wnt1)1Hev/0
FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev 		decreased mammary gland tumor incidence J:214244
increased tumor latency J:214244
mammary gland hyperplasia J:214244
Muc1tm1Gend/Muc1tm1Gend
Tg(Wnt1)1Hev/?
involves: FVB 		decreased tumor growth/size J:82470
Ptentm1Rps/Pten+
Tg(Wnt1)1Hev/0
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL 		increased adenocarcinoma incidence J:67497
increased mammary adenocarcinoma incidence J:67497
increased mammary gland ductal carcinoma incidence J:67497
increased metastatic potential J:67497
increased salivary adenocarcinoma incidence J:67497
Sdc1tm1Cma/Sdc1+
Tg(Wnt1)1Hev/0
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased tumor incidence J:63122
Sdc1tm1Cma/Sdc1tm1Cma
Tg(Wnt1)1Hev/0
involves: 129S4/SvJae * C57BL/6 * SJL 		decreased tumor incidence J:63122
mammary gland hyperplasia J:63122
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
involves: C3H * C57BL/6 		abnormal stomach glandular epithelium morphology J:116782
decreased tumor-free survival time J:116782
gastric metaplasia J:116782
increased gastric adenocarcinoma incidence J:116782
increased stomach tumor incidence J:116782, J:153058
Wnt1tm1.1Mze/Wnt1tm1.1Mze
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
En1tm2(cre)Wrst/En1+
involves: 129 * C57BL/6N 		abnormal hindbrain morphology J:194842
abnormal innervation J:194842
abnormal midbrain morphology J:194842
abnormal rhombomere morphology J:194842
decreased neuron number J:194842
decreased neuronal precursor cell number J:194842
Wnt1tm1.1Mze/Wnt1tm1.1Mze
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S6/SvEvTac * C57BL/6N 		abnormal midbrain morphology J:194842
decreased neuron number J:194842
premature neuronal precursor differentiation J:194842
Wnt1tm1.1Mze/Wnt1tm1.1Mze
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Wnt1-cre/ERT)1Alj/0
involves: 129S6/SvEvTac * C57BL/6N * Swiss Webster 		abnormal midbrain morphology J:194842
Wnt1tm1Brd/Wnt1tm1Brd
Wnt3atm1Amc/Wnt3atm1Amc
involves: 129S1/Sv * 129S7/SvEvBrd 		abnormal dermomyotome development J:50279
abnormal dorsal-ventral axis patterning J:44094
abnormal forebrain development J:44094
abnormal melanoblast morphology J:44094
abnormal metencephalon morphology J:44094
abnormal midbrain development J:44094
abnormal myotome development J:50279
abnormal neural crest cell morphology J:44094
abnormal thyroid cartilage morphology J:44094
absent hyoid bone J:44094
absent stapes J:44094
caudal body truncation J:44094
embryonic lethality during organogenesis, incomplete penetrance J:44094
lethality throughout fetal growth and development, incomplete penetrance J:44094
small alisphenoid bone J:44094
small basisphenoid bone J:44094
small dorsal root ganglion J:44094
small otic capsule J:44094
small presphenoid bone J:44094
small temporal bone squamous part J:44094
Wnt1tm1Brd/Wnt1tm1Brd
Wnt4tm1Amc/Wnt4tm1Amc
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J 		decreased thymocyte number J:75999
Wnt1tm1Brd/Wnt1tm1Brd
Wnt8atm1(KOMP)Vlcg/Wnt8atm1(KOMP)Vlcg
involves: 129S7/SvEvBrd * C57BL/6NTac 		abnormal endolymphatic duct morphology J:194132
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory