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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccl2
C-C motif chemokine ligand 2
MGI:98259
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ccl2tm1Rol/Ccl2+
Mpztm1Msch/Mpz+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal macrophage derived foam cell morphology J:133028
decreased macrophage cell number J:133028
demyelination J:133028
neuron degeneration J:133028
Ccl2tm1Rol/Ccl2+
Tg(PMP22)C61Clh/0
involves: 129S4/SvJae * C57BL/6J * CBA/Ca 		decreased grip strength J:158350
demyelination J:158350
increased macrophage cell number J:158350
Ccl2tm1Rol/Ccl2tm1Rol
Ccr2tm1Mae/Ccr2tm1Mae
B6.129-Ccr2tm1Mae Ccl2tm1Rol 		alcohol aversion J:102583
alcohol preference J:102583
decreased alcohol consumption J:102583
Ccl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J 		abnormal amacrine cell morphology J:200877
abnormal Bruch membrane morphology J:200877
abnormal macrophage physiology J:200877
abnormal microglial cell morphology J:200877
abnormal Muller cell morphology J:200877
abnormal photoreceptor inner segment morphology J:200877
abnormal retina morphology J:200877
abnormal retina pigmentation J:200877
disorganized photoreceptor outer segment J:200877
increased microglial cell activation J:200877
increased susceptibility to age-related retinal degeneration J:200877
retina photoreceptor degeneration J:200877
retina pigment epithelium atrophy J:200877
Ccl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Zm/Cx3cr1tm1Zm
involves: 129 * 129S4/SvJae 		abnormal Bruch membrane morphology J:126935
abnormal retina morphology J:126935
abnormal retina pigment epithelium morphology J:126935
abnormal retina pigmentation J:126935
choroidal neovascularization J:126935
decreased litter size J:126935
disorganized photoreceptor outer segment J:126935
retina deposits J:126935
retina photoreceptor degeneration J:126935
retina pigment epithelium atrophy J:126935
retina pigment epithelium hyperplasia J:126935
variable depigmentation J:126935
Ccl2tm1Rol/Ccl2tm1Rol
Ldlrtm1Her/Ldlrtm1Her
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		decreased susceptibility to atherosclerosis J:75837
increased circulating triglyceride level J:75837
increased circulating VLDL cholesterol level J:75837
Ccl2tm1Rol/Ccl2tm1Rol
Mpztm1Msch/Mpz+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal cytokine level J:133028
decreased macrophage cell number J:133028
demyelination J:133028
increased macrophage cell number J:133028
neuron degeneration J:133028
Ccl2tm1Rol/Ccl2tm1Rol
Tg(PMP22)C61Clh/0
involves: 129S4/SvJae * C57BL/6J * CBA/Ca 		abnormal action potential J:158350
abnormal grip strength J:158350
decreased nerve conduction velocity J:158350
demyelination J:158350
increased macrophage cell number J:158350
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory