82 phenotypes from 11 alleles in 16 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz involves: 129P2/OlaHsd * C57BL/6	abnormal double-negative T cell morphology	J:90487
	abnormal double-positive T cell morphology	J:90487
	abnormal T cell morphology	J:90487
	decreased T cell number	J:90487
Rag2m1Btlr/Rag2m1Btlr C57BL/6J-Rag2m1Btlr	abnormal humoral immune response	J:203045
	decreased B cell number	J:203045
	decreased CD4-positive, alpha-beta T cell number	J:203045
	decreased IgG level	J:203045
	decreased IgM level	J:203045
Rag2tm1.1Cgn/Rag2tm1.1Cgn C57BL/6-Rag2tm1.1Cgn	arrested B cell differentiation	J:72214
	arrested T cell differentiation	J:72214
Rag2tm1.1Desi/Rag2tm1.1Desi involves: 129X1/SvJ * C57BL/6	abnormal immunoglobulin V(D)J recombination	J:168974
Rag2tm1Avla/Rag2tm1Avla involves: 129/Sv * C57BL/6	abnormal B cell physiology	J:122108
	abnormal digestive system morphology	J:122108
	abnormal immune system cell morphology	J:122108
	abnormal immune system organ morphology	J:122108
	abnormal lymph node morphology	J:122108
	abnormal lymphocyte physiology	J:122108
	abnormal spleen morphology	J:122108
	abnormal thymus morphology	J:122108
	absent Hassall's corpuscle	J:122108
	absent Peyer's patches	J:122108
	alopecia	J:122108
	arrested B cell differentiation	J:122108
	arrested T cell differentiation	J:122108
	cachexia	J:122108
	colitis	J:122108
	decreased double-positive T cell number	J:122108
	decreased IgA level	J:122108
	decreased IgG level	J:122108
	decreased lymphocyte cell number	J:122108
	decreased NK T cell number	J:122108
	decreased spleen white pulp amount	J:122108
	decreased T cell proliferation	J:122108
	erythroderma	J:122108
	small cervical lymph nodes	J:122108
	small inguinal lymph nodes	J:122108
	small lymph nodes	J:122108
	small spleen	J:122108
Rag2tm1Cgn/Rag2tm1.1Cgn Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal B cell activation	J:72214
	absent immature B cells	J:72214
	absent pre-B cells	J:72214
	arrested B cell differentiation	J:72214
	arrested T cell differentiation	J:72214
	decreased follicular B cell number	J:72214
	decreased marginal zone B cell number	J:72214
	decreased mature B cell number	J:72214
	increased plasma cell number	J:72214
Rag2tm1Cgn/Rag2tm1Cgn C57BL/6-Rag2tm1Cgn	no abnormal phenotype detected	J:72214
Rag2tm1Fwa/Rag2tm1Fwa either: (involves: 129S/SvEv * BALB/c) or (involves: 129S/SvEv * C57BL/6)	abnormal intestinal epithelium morphology	J:126867
Rag2tm1Fwa/Rag2tm1Fwa involves: 129S/SvEv	abnormal chemokine secretion	J:140483
	abnormal interferon secretion	J:140483
	abnormal macrophage physiology	J:140483
	abnormal response to transplant	J:116136
	abnormal T-helper 1 physiology	J:116136
	colitis	J:116136
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:140483
	decreased thymocyte number	J:114561
	increased susceptibility to bacterial infection	J:140483
	lung inflammation	J:140483
Rag2tm1Fwa/Rag2tm1Fwa involves: 129S/SvEv * C57BL/6	abnormal B cell morphology	J:81133
	abnormal intestinal mucosa morphology	J:64232
	abnormal stomach mucosa morphology	J:64232
	arrested T cell differentiation	J:91542
	decreased double-negative T cell number	J:81133, J:91542
	decreased susceptibility to parasitic infection	J:64283
	decreased susceptibility to type IV hypersensitivity reaction	J:165513
	increased double-negative T cell number	J:91542
Rag2tm1Fwa/Rag2tm1Fwa involves: 129S/SvEv * MF1	abnormal effector T cell morphology	J:1935
	abnormal immunoglobulin V(D)J recombination	J:1935
	abnormal spleen morphology	J:1935
	abnormal T cell receptor V(D)J recombination	J:1935
	absent mature B cells	J:1935
	arrested B cell differentiation	J:1935
	arrested T cell differentiation	J:1935
	decreased body size	J:1935
	decreased CD4-positive, alpha-beta T cell number	J:1935
	decreased CD8-positive, alpha-beta T cell number	J:1935
	decreased double-positive T cell number	J:1935
	decreased IgM level	J:1935
	increased granulocyte number	J:1935
	increased macrophage cell number	J:1935
	increased natural killer cell mediated cytotoxicity	J:1935
	increased susceptibility to infection	J:1935
	lymph node hypoplasia	J:1935
	spleen hypoplasia	J:1935
	thymus hypoplasia	J:1935
Rag2tm1Fwa/Rag2tm1Mao involves: 129S/SvEv * C57BL/6	abnormal B cell number	J:81837
	abnormal gamma-delta T cell differentiation	J:81837
	arrested B cell differentiation	J:81837
	arrested T cell differentiation	J:81837
	decreased double-negative T cell number	J:81837
	decreased immature B cell number	J:81837
	decreased mature B cell number	J:81837
	decreased pre-B cell number	J:81837
	increased immature B cell number	J:81837
	thymus hypoplasia	J:81837
Rag2tm1Libo/Rag2tm1Libo involves: 129S6/SvEvTac * C57BL/6 * FVB/N	abnormal B cell differentiation	J:84563
	abnormal B cell physiology	J:84563
	decreased B cell number	J:84563
	decreased bone marrow cell number	J:84563
	decreased monocyte cell number	J:84563
	decreased pre-B cell number	J:84563
Rag2tm1Mao/Rag2tm1Mao involves: 129 * C57BL/6	abnormal B cell number	J:81837
	abnormal gamma-delta T cell differentiation	J:81837
	arrested B cell differentiation	J:81837
	arrested T cell differentiation	J:81837
	decreased double-negative T cell number	J:81837
	decreased immature B cell number	J:81837
	decreased mature B cell number	J:81837
	decreased pre-B cell number	J:81837
	increased immature B cell number	J:81837
	thymus hypoplasia	J:81837
Rag2tm1Mao/Rag2tm1Mao involves: 129S6/SvEvTac * C57BL/6	abnormal immune system cell morphology	J:81837
Rag2tm1Tgi/Rag2tm1Tgi involves: 129S1/Sv * 129X1/SvJ	abnormal Peyer's patch morphology	J:113641
	arrested B cell differentiation	J:113641
	arrested T cell differentiation	J:113641
	decreased B cell number	J:113641
	decreased double-positive T cell number	J:113641
	decreased thymocyte number	J:113641
Rag2tm2Fwa/Rag2tm2Fwa involves: 129S6/SvEvTac	no abnormal phenotype detected	J:57268