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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Prkcq
protein kinase C, theta
MGI:97601
32 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Crb1rd8/Crb1rd8
Prkcqtm1Litt/Prkcqtm1Litt
B6.129P2-Prkcqtm1Litt
abnormal ocular fundus morphology J:237977
decreased eye pigmentation J:237977
retinal degeneration J:237977
retinal detachment J:237977
Pde6brd1/Pde6brd1
Prkcqrpea1/Prkcqrpea1
ABJ/LeJ-Prkcqrpea1/Boc
abnormal ocular fundus morphology J:237977
buphthalmos J:237977
cataract J:237977
decreased retinal ganglion cell number J:237977
decreased retinal photoreceptor cell number J:237977
ocular hypertension J:237977
Pde6brd1/Pde6brd1
Prkcqrpea1/Prkcqrpea1
B6.ABJ-Prkcqrpea1 Pde6brd1/Boc
abnormal ocular fundus morphology J:237977
buphthalmos J:237977
cataract J:237977
decreased retinal ganglion cell number J:237977
decreased retinal photoreceptor cell number J:237977
ocular hypertension J:237977
retinal detachment J:237977
serous retinal detachment J:237977
Prkchtm1.2Gasc/Prkchtm1.2Gasc
Prkcqtm1Litt/Prkcqtm1Litt
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
abnormal positive T cell selection J:186080
decreased CD4-positive, alpha beta T cell number J:186080
decreased CD8-positive, alpha-beta T cell number J:186080
decreased DN1 thymic pro-T cell number J:186080
decreased DN4 thymocyte number J:186080
decreased double-negative T cell number J:186080
decreased double-positive T cell number J:186080
decreased T cell proliferation J:186080
normal immune system phenotype J:186080
Prkcqtm1Litt/Prkcqtm1Litt
Tcratm1Mom/Tcratm1Mom
involves: 129P2/OlaHsd * 129S2/SvPas
decreased interleukin-4 secretion J:135589
decreased T cell proliferation J:135589
normal digestive/alimentary phenotype J:135589
normal immune system phenotype J:135589
Prkcqtm1Litt/Prkcqtm1Litt
Tg(DO11.10)10Dlo/0
involves: 129 * BALB/c * C3H * C57BL/6
decreased T cell apoptosis J:141930
Prkcqtm1Litt/Prkcqtm1Litt
Tg(Lck-Notch3)#Issc/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
decreased lymphoma incidence J:96010
enlarged chest J:96010
enlarged spleen J:96010
extended life span J:96010
increased spleen weight J:96010
premature death J:96010
Prkcqtm1Litt/Prkcqtm1Litt
Tg(LCKprBCL2L1)12Sjk/0
involves: 129P2/OlaHsd * C57BL/6
decreased NK T cell number J:141128
normal immune system phenotype J:141128
Prkcqtm1Litt/Prkcqtm1Litt
Tg(TcrLCMV)327Sdz/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
abnormal T cell anergy J:123989
decreased cytotoxic T cell cytolysis J:123989
decreased splenocyte proliferation J:123989
decreased T cell proliferation J:123989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory