38 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2atm1.1Brn/Cdkn2a+ Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * 129S7/SvEvBrd	increased mesothelioma incidence	J:132943
	increased metastatic potential	J:132943
	increased rhabdomyosarcoma incidence	J:132943
	increased tumor incidence	J:132943
	pleural effusion	J:132943
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn Nf2tm2Gth/Nf2tm2Gth involves: 129P2/OlaHsd * FVB/N	abnormal meninges morphology	J:131179
	hydrocephaly	J:131179
	increased liver tumor incidence	J:131179
	increased meningioma incidence	J:131179
	increased osteoma incidence	J:131179
	osseous metaplasia	J:131179
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn Nf2tm2Gth/Nf2tm2Gth Ptgdstm1.1(cre)Gvn/Ptgds+ involves: 129P2/OlaHsd * FVB/N	increased meningioma incidence	J:173718
	normal mortality/aging	J:173718
	normal neoplasm	J:173718
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * 129S7/SvEvBrd	increased mesothelioma incidence	J:132943
	increased rhabdomyosarcoma incidence	J:132943
	increased Schwannoma incidence	J:132943
	increased tumor incidence	J:132943
	premature death	J:132943
Cdkn2atm2Brn/Cdkn2a+ Nf2tm2Gth/Nf2tm2Gth involves: 129P2/OlaHsd	enlarged liver	J:132943
	increased leukemia incidence	J:132943
	increased tumor incidence	J:132943
	increased uterus leiomyoma incidence	J:132943
	premature death	J:132943
Cdkn2atm2Brn/Cdkn2atm2Brn Nf2tm2Gth/Nf2+ involves: 129P2/OlaHsd	increased leukemia incidence	J:132943
	increased tumor incidence	J:132943
	increased uterus leiomyoma incidence	J:132943
	premature death	J:132943
Cdkn2atm2Brn/Cdkn2atm2Brn Nf2tm2Gth/Nf2tm2Gth involves: 129P2/OlaHsd	enlarged liver	J:132943
	increased leukemia incidence	J:132943
	increased rhabdomyosarcoma incidence	J:132943
	increased tumor incidence	J:132943
	increased uterus leiomyoma incidence	J:132943
	premature death	J:132943
Hrastm1Jaf/Hrastm1Jaf Nf2tm2Gth/Nf2tm2Gth Tg(TPO-cre)1Shk/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr	increased thyroid tumor incidence	J:231492
Nf2tm2Gth/Nf2+ Trp53tm1Brd/Trp53+ Tg(Mpz-cre)3Brn/0 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N	increased neurofibrosarcoma incidence	J:92413
	increased osteoma incidence	J:92413
	increased osteosarcoma incidence	J:92413
	increased skeletal tumor incidence	J:92413
	premature death	J:92413
Nf2tm2Gth/Nf2+ Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * 129S7/SvEvBrd	increased leukemia incidence	J:132943
	increased mesothelioma incidence	J:132943
	increased Schwannoma incidence	J:132943
	increased tumor incidence	J:132943
	increased uterus leiomyoma incidence	J:132943
	premature death	J:132943
Nf2tm2Gth/Nf2tm2Gth Ptgdstm1.1(cre)Gvn/Ptgds+ Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * FVB/N	increased nervous system tumor incidence	J:173718
	increased osteosarcoma incidence	J:173718
	premature death	J:173718
Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brd/Trp53+ Tg(Mpz-cre)2Brn/0 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N	abnormal osteoblast morphology	J:92413
	abnormal renal tubule morphology	J:92413
	abnormal Schwann cell morphology	J:92413
	abnormal tooth development	J:92413
	cataract	J:92413
	decreased survivor rate	J:92413
	increased leiomyosarcoma incidence	J:92413
	increased nervous system tumor incidence	J:92413
	increased neurofibroma incidence	J:92413
	increased neurofibrosarcoma incidence	J:92413
	increased sarcoma incidence	J:92413
	increased Schwannoma incidence	J:92413
	osseous metaplasia	J:92413
	premature death	J:92413
Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brd/Trp53+ Tg(Mpz-cre)3Brn/0 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N	decreased survivor rate	J:92413
	increased neurofibrosarcoma incidence	J:92413
	premature death	J:92413
Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brd/Trp53tm1Brd Tg(Mpz-cre)2Brn/0 involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N	abnormal osteoblast morphology	J:92413
	abnormal renal tubule morphology	J:92413
	abnormal Schwann cell morphology	J:92413
	cataract	J:92413
	increased extremity angiosarcoma incidence	J:92413
	increased neurofibrosarcoma incidence	J:92413
	increased osteoma incidence	J:92413
	increased osteosarcoma incidence	J:92413
	increased rhabdomyosarcoma incidence	J:92413
	increased sarcoma incidence	J:92413
	increased tumor incidence	J:92413
	osseous metaplasia	J:92413
	premature death	J:92413
Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brn/Trp53+ involves: 129P2/OlaHsd * 129S7/SvEvBrd	enlarged liver	J:132943
	increased leukemia incidence	J:132943
	increased mesothelioma incidence	J:132943
	increased Schwannoma incidence	J:132943
	increased tumor incidence	J:132943
	increased uterus leiomyoma incidence	J:132943
	premature death	J:132943
Nf2tm2Gth/Nf2tm2Gth Trp53tm1Brn/Trp53tm1Brn involves: 129P2/OlaHsd * 129S7/SvEvBrd	enlarged liver	J:132943
	increased leukemia incidence	J:132943
	increased mesothelioma incidence	J:132943
	increased rhabdomyosarcoma incidence	J:132943
	increased Schwannoma incidence	J:132943
	increased T cell derived lymphoma incidence	J:132943
	increased tumor incidence	J:132943
	increased uterus leiomyoma incidence	J:132943
	premature death	J:132943
Nf2tm2Gth/Nf2tm2Gth Yap1tm1.1Dupa/Yap1+ Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * C57BL/6 * DBA	enlarged liver	J:162628
	normal liver/biliary system phenotype	J:162628
	normal neoplasm	J:162628
Nf2tm2Gth/Nf2tm2Gth Yap1tm1.1Dupa/Yap1tm1.1Dupa Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: 129P2/OlaHsd * C57BL/6 * DBA	normal liver/biliary system phenotype	J:162628
	normal neoplasm	J:162628
Nf2tm2Gth/Nf2tm2Gth Yap1tm2.1Dupa/Yap1tm2.1Dupa involves: 129P2/OlaHsd	abnormal bile duct epithelium morphology	J:223215
	abnormal bile duct physiology	J:223215
	enlarged liver	J:223215
	increased hamartoma incidence	J:223215