Irf1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf1
interferon regulatory factor 1
MGI:96590

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fas^lpr/Fas^lpr Irf1^tm1Mak/Irf1⁺ MRL.Cg-Irf1^tm1Mak Fas^lpr	abnormal skin condition	J:114771
	glomerulonephritis	J:114771
	normal immune system phenotype	J:114771
	increased anti-double stranded DNA antibody level	J:114771
	increased CD4-positive, alpha-beta T cell number	J:114771
	increased urine protein level	J:114771
	premature death	J:114771
Fas^lpr/Fas^lpr Irf1^tm1Mak/Irf1^tm1Mak MRL.Cg-Irf1^tm1Mak Fas^lpr	abnormal cell physiology	J:114771
	abnormal cytokine secretion	J:114771
	decreased anti-double stranded DNA antibody level	J:114771
	glomerulonephritis	J:114771
	normal homeostasis/metabolism phenotype	J:114771
	normal immune system phenotype	J:114771
	increased CD4-positive, alpha-beta T cell number	J:114771
	normal integument phenotype	J:114771
	premature death	J:114771
Irf1^tm1Mak/Irf1^tm1Mak Tg(HRAS)2Jic/? involves: 129S2/SvPas * BALB/c * C57BL/6	increased hemangiosarcoma incidence	J:55418
	increased tumor incidence	J:55418
Irf1^tm1Mak/Irf1^tm1Mak Trp53^tm1Sia/Trp53^tm1Sia involves: 129S2/SvPas * C57BL/6 * CBA	decreased tumor-free survival time	J:55418
	increased hemangiosarcoma incidence	J:55418
	increased lymphoma incidence	J:55418
	increased teratoma incidence	J:55418
	increased tumor incidence	J:55418

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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