Trp53^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Sia
• Name: transformation related protein 53; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:1926340
• Synonyms: p53^-
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36762
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the second exon of the gene, disrupting the translation initiation codon. (J:36762)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Sia

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 10 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:36762 Tsukada T, et al., Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene. 1993 Dec;8(12):3313-22
• All: 85 reference(s)