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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il7r
interleukin 7 receptor
MGI:96562
40 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il7rtm1.1(icre)Hrr/Il7r+
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:158903
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd4-cre)1Cwi/0
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 		decreased CD8-positive, alpha-beta T cell number J:190889
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
involves: 129S7/SvEvBrd * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:190889
Il7rtm1Abra/Il7rtm1Abra
B6.129S4-Il7rtm1Abra 		abnormal CD4-positive, alpha-beta T cell physiology J:125360
abnormal T cell differentiation J:125360
abnormal T cell proliferation J:125360
decreased B cell number J:125360
decreased CD4-positive, alpha-beta T cell number J:125360
decreased CD8-positive, alpha-beta T cell number J:125360
decreased memory T cell number J:125360
decreased thymocyte number J:125360
increased double-positive T cell number J:125360
Il7rtm1Iku/Il7rtm1Iku
involves: 129P2/OlaHsd * C57BL/6J 		abnormal B cell differentiation J:34658
abnormal gamma-delta T cell differentiation J:34658
abnormal T cell subpopulation ratio J:34658
absent mature gamma-delta T cells J:34658
absent Peyer's patches J:45633
decreased B-1 B cell number J:34658
decreased bone marrow cell number J:34658
decreased double-positive T cell number J:34658
decreased immature B cell number J:34658
decreased leukocyte cell number J:34658
decreased lymphocyte cell number J:34658
decreased mature B cell number J:34658
decreased T cell number J:34658
normal immune system phenotype J:34658
increased double-negative T cell number J:34658
small thymus J:34658
spleen hypoplasia J:34658
thymus hypoplasia J:34658
Il7rtm1Imx/Il7rtm1Imx
B6.129S7-Il7rtm1Imx 		abnormal T cell differentiation J:125360
decreased double-positive T cell number J:125360
decreased thymocyte number J:125360
Il7rtm1Imx/Il7rtm1Imx
involves: 129P3/J * 129S7/SvEvBrd 		arrested B cell differentiation J:21135
arrested T cell differentiation J:21135
decreased B cell number J:21135
decreased T cell number J:21135
lymph node hypoplasia J:21135
spleen hypoplasia J:21135
thymus hypoplasia J:21135
Il7rtm1Imx/Il7rtm1Imx
involves: 129S7/SvEvBrd 		decreased thymocyte number J:64861
Il7rtm1Imx/Il7rtm1Imx
Tg(Lck-Il7r)1676Trma/?
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		decreased T cell proliferation J:66400
decreased thymocyte number J:66400
increased thymocyte apoptosis J:66400
Il7rtm2Iku/Il7rtm2Iku
Tg(Cd4-cre)1Cwi/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal CD4-positive T cell differentiation J:193283
abnormal CD8-positive, alpha-beta T cell differentiation J:193283
abnormal T cell morphology J:193283
decreased NK T cell number J:193283
increased B cell number J:193283
increased gamma-delta T cell number J:193283
increased thymocyte number J:193283
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory