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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Il2rg
interleukin 2 receptor, gamma chain
MGI:96551
82 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd4-cre)1Cwi/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:190889
decreased CD8-positive, alpha-beta T cell number J:190889
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
involves: 129S4/SvJae * C57BL/6 		decreased CD4-positive, alpha-beta T cell number J:190889
decreased CD8-positive, alpha-beta T cell number J:190889
decreased NK T cell number J:190889
decreased regulatory T cell number J:190889
Il2rgtm1.1Vlcg/Y
involves: 129S6/SvEvTac * C57BL/6NTac 		no abnormal phenotype detected J:200671
Il2rgtm1Cgn/Y
involves: 129 * CB20 		abnormal alpha-beta intraepithelial T cell morphology J:22521
abnormal class switch recombination J:22521
abnormal gamma-delta T cell differentiation J:111821
abnormal leukocyte morphology J:22521
abnormal thymocyte activation J:22521
absent gamma-delta intraepithelial T cell J:111821
absent gamma-delta T cells J:111821
absent NK cells J:22521
absent Peyer's patches J:22521
absent spleen germinal center J:22521
decreased IgE level J:22521
decreased IgM level J:22521
decreased mature B cell number J:22521
decreased plasma cell number J:22521
decreased pre-B cell number J:22521
decreased spleen white pulp amount J:22521
decreased T cell number J:22521
decreased T cell proliferation J:22521
impaired natural killer cell mediated cytotoxicity J:22521
spleen hypoplasia J:22521
thymus hypoplasia J:22521, J:111821
Il2rgtm1Cgn/Il2rgtm1Cgn
involves: 129 * CB20 		abnormal alpha-beta intraepithelial T cell morphology J:22521
abnormal class switch recombination J:22521
abnormal hematopoietic system morphology/development J:22521
abnormal leukocyte morphology J:22521
abnormal thymocyte activation J:22521
absent NK cells J:22521
absent Peyer's patches J:22521
absent spleen germinal center J:22521
decreased IgE level J:22521
decreased IgM level J:22521
decreased mature B cell number J:22521
decreased plasma cell number J:22521
decreased pre-B cell number J:22521
decreased spleen white pulp amount J:22521
decreased T cell number J:22521
decreased T cell proliferation J:22521
impaired natural killer cell mediated cytotoxicity J:22521
spleen hypoplasia J:22521
thymus hypoplasia J:22521
Il2rgtm1Krf/Il2rgtm1Krf
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N) 		decreased thymocyte number J:114561
Il2rgtm1Sug/Y
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal immune serum protein physiology J:31167
abnormal immune system cell morphology J:31167
abnormal immune system organ morphology J:31167
abnormal immunoglobulin level J:31167
abnormal myelopoiesis J:31167
abnormal proerythroblast morphology J:31167
abnormal splenic cell ratio J:31167
absent NK cells J:31167
absent spleen white pulp J:31167
arrested B cell differentiation J:31167
decreased IgG3 level J:31167
decreased IgG level J:31167
decreased lymphocyte cell number J:31167
decreased T cell number J:31167
decreased thymocyte number J:31167
enlarged Peyer's patches J:31167
enlarged spleen J:31167
increased macrophage cell number J:31167
increased megakaryocyte cell number J:31167
increased monocyte cell number J:31167
increased neutrophil cell number J:31167
small lymph nodes J:31167
small thymus J:31167
thymus cortex hypoplasia J:31167
thymus hypoplasia J:31167
Il2rgtm1Sug/Il2rgtm1Sug
B6.129-Il2rgtm1Sug 		abnormal decidua basalis morphology J:116952
abnormal estrous cycle J:116952
abnormal maternal decidual layer morphology J:116952
abnormal placenta metrial gland morphology J:116952
absent uterine NK cells J:116952
prolonged diestrus J:116952
prolonged estrous cycle J:116952
prolonged metestrus J:116952
normal reproductive system phenotype J:116952
Il2rgtm1Wjl/Y
involves: 129S4/SvJae * C57BL/6 		abnormal B cell number J:108209
abnormal basophil physiology J:24117
abnormal CD4-positive, alpha beta T cell morphology J:108209
abnormal cecum morphology J:24117
abnormal cell-mediated immunity J:108209
abnormal gut-associated lymphoid tissue morphology J:24117
abnormal immune serum protein physiology J:108209
abnormal immune system organ morphology J:108209
abnormal lymphocyte morphology J:108209
abnormal mast cell physiology J:24117
abnormal mesenteric lymph node morphology J:24117
abnormal thymocyte activation J:24117
absent gamma-delta intraepithelial T cell J:24117
absent gamma-delta T cells J:24117
absent NK cells J:24117
cecum inflammation J:24117
decreased CD8-positive, alpha-beta T cell number J:24117
decreased double-negative T cell number J:24117
decreased double-positive T cell number J:24117
decreased immature B cell number J:24117
decreased immunoglobulin level J:24117
decreased interferon-gamma secretion J:24117
decreased interleukin-2 secretion J:24117
decreased interleukin-4 secretion J:24117
decreased single-positive T cell number J:24117
decreased T cell proliferation J:24117
impaired natural killer cell mediated cytotoxicity J:24117
small lymph nodes J:24117
small thymus J:24117
small thymus cortex J:24117
spleen hyperplasia J:24117
spleen hypoplasia J:24117
thymus hyperplasia J:108209
Il2rgtm1Wjl/Il2rgtm1Wjl
B6.129S4-Il2rgtm1Wjl/J 		abnormal dendritic cell physiology J:123902
abnormal splenic cell ratio J:123902
decreased myeloid dendritic cell number J:123902
Il2rgtm2Cgn/Y
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased NK cell number J:132257
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory