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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Irf8
interferon regulatory factor 8
MGI:96395
18 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Id2tm1Gtbz/Id2tm1Gtbz
Irf8tm1Hor/Irf8tm1Hor
involves: 129P2/OlaHsd * C57BL/6
abnormal bone marrow cell morphology/development J:194760
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
BXH2/TyJ-Irf8myls
abnormal myelopoiesis J:97931
decreased interferon-gamma secretion J:97931
decreased interleukin-12 secretion J:97931
enlarged spleen J:97931
increased chronic myelocytic leukemia incidence J:97931
increased susceptibility to bacterial infection J:97931
premature death J:97931
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: A/J * BXH2/TyJ
increased chronic myelocytic leukemia incidence J:97931
premature death J:97931
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BALB/cJ * BXH2/TyJ
increased susceptibility to bacterial infection J:97931
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C3H/HeJ
enlarged spleen J:97931
increased susceptibility to bacterial infection J:97931
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C57BL/6J
increased susceptibility to bacterial infection J:97931
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BALB/cJ * BXH2/TyJ
increased susceptibility to bacterial infection J:97931
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BXH2/TyJ * C57BL/6J
increased susceptibility to bacterial infection J:97931
Irf8myls/Irf8myls
Slc11a1s/Slc11a1s
involves: BALB/cJ * BXH2/TyJ
increased susceptibility to bacterial infection J:97931
Irf8tm1Hor/Irf8tm1Hor
Irf4tm1Mak/Irf4tm1Mak
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell differentiation J:84577
abnormal pre-B cell morphology J:84577
absent B cells J:84577
arrested B cell differentiation J:84577
decreased dendritic cell number J:97716
decreased IgM level J:84577
decreased lymphocyte cell number J:84577
decreased plasmacytoid dendritic cell number J:97716
decreased T cell number J:84577
increased pre-B cell number J:84577

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory