About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grb2
growth factor receptor bound protein 2
MGI:95805
44 phenotypes from 6 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Grb2tm1.1Hua/Grb2tm1.1Hua
Tg(Lck-cre)1Jtak/0
involves: 129 * C57BL/6 		abnormal T cell differentiation J:161294
decreased CD4-positive, alpha-beta T cell number J:161294
decreased CD8-positive, alpha-beta T cell number J:161294
decreased double-positive T cell number J:161294
decreased thymocyte number J:161294
Grb2tm1a(EUCOMM)Wtsi/Grb2tm1a(EUCOMM)Wtsi
B6Brd;B6Dnk;B6N-Tyrc-Brd Grb2tm1a(EUCOMM)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Grb2tm1Lnit/Grb2tm1Lnit
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * BALB/cJ 		abnormal B cell differentiation J:171222
abnormal B cell physiology J:171222
abnormal memory B cell physiology J:171222
decreased B cell number J:171222
decreased follicular B cell number J:171222
decreased IgG3 level J:171222
decreased IgG level J:171222
decreased mature B cell number J:171222
decreased spleen germinal center number J:171222
decreased spleen germinal center size J:171222
decreased transitional stage T1 B cell number J:171222
decreased transitional stage T2 B cell number J:171222
increased B cell apoptosis J:171222
increased B cell proliferation J:171222
increased IgM level J:171222
increased plasma cell number J:171222
Grb2tm1Paw/Grb2+
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:51424
Grb2tm1Paw/Grb2+
involves: 129S1/Sv * 129X1/SvJ * BALB/c 		decreased susceptibility to Retroviridae infection J:122429
Grb2tm1Paw/Grb2tm1Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal endoderm development J:51424
absent inner cell mass proliferation J:51424
embryonic lethality between implantation and somite formation, complete penetrance J:51424
Grb2tm1Paw/Grb2tm2Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal facial nerve morphology J:69138
abnormal heart development J:69138
abnormal otic vesicle development J:69138
abnormal vagus nerve morphology J:69138
absent second pharyngeal arch J:69138
decreased placental labyrinth size J:69138
embryonic lethality during organogenesis, complete penetrance J:69138
failure of chorioallantoic fusion J:69138
Grb2tm1Paw/Grb2tm3.1Paw
Tg(Nphs2-cre)1Seq/0
involves: 129S1/Sv * 129X1/SvJ 		normal renal/urinary system phenotype J:195444
Grb2tm2Paw/Grb2tm2Paw
Not Specified 		abnormal mandible morphology J:69138
absent gastric milk in neonates J:69138
cleft secondary palate J:69138
decreased body length J:69138
decreased placental labyrinth size J:69138
edema J:69138
hemorrhage J:69138
neonatal lethality, complete penetrance J:69138
palatal shelves fail to meet at midline J:69138
Grb2tm3.1Paw/Grb2tm3.1Paw
Tg(Nphs1-cre)2Seq/0
involves: 129S1/Sv * 129X1/SvJ 		normal renal/urinary system phenotype J:195444
Grb2tm3.1Paw/Grb2tm3.1Paw
Tg(Nphs2-cre)1Seq/0
involves: 129S1/Sv * 129X1/SvJ 		normal renal/urinary system phenotype J:195444
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory