Grb2^tm2Paw
Targeted Allele Detail

Summary

• Symbol: Grb2^tm2Paw
• Name: growth factor receptor bound protein 2; targeted mutation 2, Tony Pawson
• MGI ID: MGI:2677457
• Synonyms: E89K
• Gene: Grb2 Location: Chr11:115534871-115599423 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Grb2^tm2Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69138
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A G-to-A mutation was introduced into codon 89 to alter this residue in the corresponding protein from a glutamate to a lysine through homologous recombination. A loxP-flanked neomycin selection cassette also introduced into intron 2 was deleted by cre-mediated recombination, resulting in a single loxP site remaining in the intron. This allele expresses a mutant protein and is thought to be hypomorphic. (J:69138)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb2 Mutation: 45 strains or lines available

References

• Original: J:69138 Saxton TM, et al., Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis. Curr Biol. 2001 May 1;11(9):662-70
• All: 2 reference(s)