Edn2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Edn2
endothelin 2
MGI:95284

45 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(CAG-cre/Esr1)5Amc/0 involves: 129S1/Sv 129X1/SvJ * C57BL/6 * CBA	abnormal pulmonary alveolar sac morphology	J:201436
	abnormal pulmonary alveolus morphology	J:201436
	acidemia	J:201436
	acidosis	J:201436
	decreased body temperature	J:201436
	decreased body weight	J:201436
	decreased circulating glucose level	J:201436
	decreased total body fat amount	J:201436
	hypercapnia	J:201436
	impaired adaptive thermogenesis	J:201436
	increased circulating bicarbonate level	J:201436
	postnatal growth retardation	J:201436
	postnatal lethality, incomplete penetrance	J:201436
	premature death	J:201436
Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(Nes-cre)1Kln/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	normal growth/size/body region phenotype	J:201436
	normal homeostasis/metabolism phenotype	J:201436
Edn2^tm1.1Nat/Edn2^tm1.1Nat Tg(Vil1-cre)997Gum/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	normal digestive/alimentary phenotype	J:201436
	normal growth/size/body region phenotype	J:201436
	normal homeostasis/metabolism phenotype	J:201436
	normal mortality/aging	J:201436
Edn2^tm1.2Nat/Edn2^tm1.2Nat involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased body size	J:201133
	postnatal lethality, complete penetrance	J:201133
	normal vision/eye phenotype	J:201133
Edn2^{tm1b(KOMP)Mbp}/Edn2^{tm1b(KOMP)Mbp} C57BL/6N-Edn2^{tm1b(KOMP)Mbp}/Rbrc	preweaning lethality, complete penetrance	J:211773
Edn2^tm1Ywa/Edn2^tm1Ywa involves: 129S6/SvEvTac	abnormal blood homeostasis	J:201436
	abnormal brown adipose tissue morphology	J:201436
	abnormal gas homeostasis	J:201436
	abnormal lipolysis	J:201436
	abnormal pulmonary alveolar sac morphology	J:201436
	abnormal pulmonary alveolus morphology	J:201436
	acidemia	J:201436
	acidosis	J:201436
	decreased body size	J:201436
	decreased body temperature	J:201436
	decreased body weight	J:201436
	decreased circulating glucose level	J:201436
	decreased circulating triiodothyronine level	J:201436
	normal digestive/alimentary phenotype	J:201436
	normal homeostasis/metabolism phenotype	J:201436
	hypercapnia	J:201436
	hypoxia	J:201436
	impaired adaptive thermogenesis	J:201436
	increased blood urea nitrogen level	J:201436
	increased blood uric acid level	J:201436
	increased circulating bicarbonate level	J:201436
	increased circulating erythropoietin level	J:201436
	increased circulating ketone body level	J:201436
	increased hematocrit	J:201436
	increased susceptibility to induced morbidity/mortality	J:201436
	increased total lung capacity	J:201436
	postnatal growth retardation	J:201436
	postnatal lethality, incomplete penetrance	J:201436
	premature death	J:201436
Edn2^tm1Ywa/Edn2^tm1Ywa involves: 129S6/SvEvTac * C57BL/6	abnormal ovarian medulla morphology	J:215159
	absent corpus luteum	J:215159
	blood vessel congestion	J:215159
	decreased body size	J:215159
	decreased circulating progesterone level	J:215159
	decreased superovulation rate	J:215159
	decreased survivor rate	J:215159
	impaired luteal cell differentiation	J:215159
	premature death	J:215159
	small ovary	J:215159
	small uterus	J:215159
	weakness	J:215159

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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