Dmd Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dmd
dystrophin, muscular dystrophy
MGI:94909

128 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Barx2^tm1Rsd/Barx2^tm1Rsd Dmd^mdx/Y involves: 129 * C57BL/6 * C57BL/10ScSn	abnormal diaphragm morphology	J:187799
	abnormal gait	J:187799
	decreased body size	J:187799
	decreased locomotor activity	J:187799
	decreased muscle weight	J:187799
	impaired skeletal muscle regeneration	J:187799
	increased variability of skeletal muscle fiber size	J:187799
	kyphosis	J:187799
	postnatal lethality, incomplete penetrance	J:187799
	progressive muscle weakness	J:187799
	skeletal muscle endomysial fibrosis	J:187799
	skeletal muscle fiber necrosis	J:187799
	skeletal muscle fibrosis	J:187799
	thin diaphragm muscle	J:187799
Barx2^tm1Rsd/Barx2^tm1Rsd Dmd^mdx/Dmd^mdx involves: 129 * C57BL/6 * C57BL/10ScSn	abnormal diaphragm morphology	J:187799
	abnormal gait	J:187799
	decreased body size	J:187799
	decreased locomotor activity	J:187799
	decreased muscle weight	J:187799
	impaired skeletal muscle regeneration	J:187799
	increased variability of skeletal muscle fiber size	J:187799
	kyphosis	J:187799
	postnatal lethality, incomplete penetrance	J:187799
	progressive muscle weakness	J:187799
	skeletal muscle endomysial fibrosis	J:187799
	skeletal muscle fiber necrosis	J:187799
	skeletal muscle fibrosis	J:187799
	thin diaphragm muscle	J:187799
Cav3^tm1Ncnp/Cav3⁺ Dmd^mdx/Dmd^mdx involves: 129S4/SvJae * C57BL/10 * C57BL/10ScSn	abnormal intercostal muscle morphology	J:150127
	abnormal muscle development	J:150127
	abnormal muscle fiber morphology	J:150127
	centrally nucleated skeletal muscle fibers	J:150127
Cmah^tm1Avrk/Cmah^tm1Avrk Dmd^mdx/Dmd^mdx involves: 129X1/SvJ * C57BL/10ScSn	abnormal gait	J:164594
	cardiac muscle necrosis	J:164594
	dystrophic muscle	J:164594
	impaired coordination	J:164594
	increased macrophage cell number	J:164594
	increased monocyte cell number	J:164594
	muscle weakness	J:164594
	premature death	J:164594
	skeletal muscle fibrosis	J:164594
Creb1^tm1.1Berd/Creb1^tm1.1Berd Dmd^mdx/Y B.Cg-Creb1^tm1.1Berd Dmd^mdx	enhanced skeletal muscle regeneration	J:177923
	skeletal muscle degeneration	J:177923
Ctss^tm1Hap/Ctss^tm1Hap Dmd^mdx/Dmd^mdx involves: 129S2/SvPas * C57BL/10ScSn	abnormal skeletal muscle fiber morphology	J:230788
	centrally nucleated skeletal muscle fibers	J:230788
	dystrophic muscle	J:230788
	impaired exercise endurance	J:230788
	increased circulating creatine kinase level	J:230788
	skeletal muscle fiber necrosis	J:230788
	skeletal muscle fibrosis	J:230788
Dag1^tm1.1Swin/Dag1^tm1.1Swin Dmd^mdx/Y involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn	centrally nucleated skeletal muscle fibers	J:187750
	increased circulating creatine kinase level	J:187750
	increased susceptibility to injury	J:187750
Dag1^tm1.1Swin/Dag1^tm1.1Swin Dmd^mdx/Dmd^mdx involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn	centrally nucleated skeletal muscle fibers	J:187750
	increased circulating creatine kinase level	J:187750
	increased susceptibility to injury	J:187750
Dmd^mdx-3Cv/Dmd^mdx-3Cv Utrn^tm1Ked/Utrn^tm1Ked involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus	abnormal skeletal muscle morphology	J:116348
	normal liver/biliary system phenotype	J:116348
	normal nervous system phenotype	J:116348
	normal renal/urinary system phenotype	J:116348
	normal reproductive system phenotype	J:116348
	normal respiratory system phenotype	J:116348
Dmd^mdx-3Cv/Y Utrn^tm1Ked/Utrn^tm1Ked involves: 129 * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus	abnormal skeletal muscle morphology	J:116348
	normal liver/biliary system phenotype	J:116348
	normal nervous system phenotype	J:116348
	normal renal/urinary system phenotype	J:116348
	normal reproductive system phenotype	J:116348
	normal respiratory system phenotype	J:116348
Dmd^mdx-4Cv/Dmd^mdx-4Cv Myf5^tm2Tajb/Myf5^tm2Tajb involves: 129S2/SvPas * C3H/HeHa * C57BL * M. m. castaneus * M. m. musculus	increased skeletal muscle fiber diameter	J:128921
	skeletal muscle fiber necrosis	J:128921
Dmd^mdx-4Cv/Dmd^mdx-4Cv Terc^tm1Rdp/Terc^tm1Rdp B6.Cg-Terc^tm1Rdp Dmd^mdx-4Cv	abnormal mitochondrial shape	J:200365
	abnormal myocardial fiber morphology	J:200365
	cardiac fibrosis	J:200365
	decreased mitochondrial size	J:200365
	decreased telomere length	J:200365
	decreased ventricle muscle contractility	J:200365
	dilated cardiomyopathy	J:200365
	dilated heart left ventricle	J:200365
	disorganized mitochondrial cristae	J:200365
	increased heart left ventricle size	J:200365
	increased mitochondrial number	J:200365
	oxidative stress	J:200365
	premature death	J:200365
	prolonged QRS complex duration	J:200365
	ventricular cardiomyopathy	J:200365
Dmd^mdx-5Cv/Dmd^mdx-5Cv Flt1^tm1Jrt/Flt1⁺ involves: C3HA * C57BL/6Ros	abnormal blood circulation	J:164891
	abnormal muscle contractility	J:164891
	abnormal muscle development	J:164891
	abnormal skeletal muscle fiber morphology	J:164891
	abnormal skeletal muscle fiber size	J:164891
	increased capillary density	J:164891
	increased satellite cell number	J:164891
	normal muscle phenotype	J:164891
Dmd^mdx-5Cv/Dmd^mdx-5Cv Flt1^tm1Jrt/Flt1⁺ Utrn^tm1Jrs/Utrn^tm1Jrs involves: 129S1/Sv * 129X1/SvJ * C3HA * C57BL/6Ros	centrally nucleated skeletal muscle fibers	J:164891
	extended life span	J:164891
	increased body weight	J:164891
Dmd^mdx/Dmd⁺ Nos1^tm1Plh/Nos1^tm1Plh involves: 129S4/SvJae * C57BL/10ScSn	abnormal circulating pyruvate kinase level	J:48851
	dystrophic muscle	J:48851
Dmd^mdx/Dmd⁺ Foxk1^tm1Djg/Foxk1⁺ involves: 129S4/SvJae * C57BL/10ScSn	decreased body size	J:62225
	skeletal muscle necrosis	J:62225
Dmd^mdx/Dmd^mdx Dusp1^tm1Brv/Dusp1^tm1Brv involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn	decreased body size	J:162340
	decreased body weight	J:162340
	decreased grip strength	J:162340
	decreased skeletal muscle fiber diameter	J:162340
	decreased skeletal muscle fiber size	J:162340
	decreased skeletal muscle weight	J:162340
	dystrophic muscle	J:162340
	myositis	J:162340
	skeletal muscle fiber degeneration	J:162340
Dmd^mdx/Dmd^mdx Foxk1^tm1Djg/Foxk1^tm1Djg involves: 129S4/SvJae * C57BL/10ScSn	decreased locomotor activity	J:62225
	postnatal lethality, incomplete penetrance	J:62225
	premature death	J:62225
	skeletal muscle fibrosis	J:62225
	skeletal muscle necrosis	J:62225
	weakness	J:62225
Dmd^mdx/Dmd^mdx Mamstr^tm1.2Eno/Mamstr^tm1.2Eno involves: 129 * C57BL/6 * C57BL/10ScSn	abnormal skeletal muscle satellite cell proliferation	J:179880
	decreased body weight	J:179880
	decreased skeletal muscle weight	J:179880
	muscle degeneration	J:179880
	skeletal muscle fibrosis	J:179880
Dmd^mdx/Dmd^mdx Mmp9^tm1Tvu/Mmp9⁺ B10.Cg-Mmp9^tm1Tvu Dmd^mdx	abnormal muscle morphology	J:150030
	abnormal muscle physiology	J:150030
	decreased macrophage cell number	J:150030
	enhanced skeletal muscle regeneration	J:150030
Dmd^mdx/Dmd^mdx Mmp9^tm1Tvu/Mmp9^tm1Tvu B10.Cg-Mmp9^tm1Tvu Dmd^mdx	abnormal muscle morphology	J:150030
	decreased macrophage cell number	J:150030
	enhanced skeletal muscle regeneration	J:150030
Dmd^mdx/Dmd^mdx Prkdc^scid/Prkdc^scid involves: BALB/c * C57BL/10ScSn * C57BL/Ka	abnormal vertebral column morphology	J:125527
	absent CD4-positive, alpha-beta T cells	J:125527
	absent CD8-positive, alpha-beta T cells	J:125527
	centrally nucleated skeletal muscle fibers	J:125527
	decreased B cell number	J:125527
	decreased transforming growth factor beta level	J:125527
	impaired exercise endurance	J:125527
	impaired skeletal muscle contractility	J:125527
	increased skeletal muscle fiber diameter	J:125527
	reduced fertility	J:125527
	skeletal muscle fiber degeneration	J:125527
	skeletal muscle fibrosis	J:125527
Dmd^mdx/Dmd^mdx Selenos^tm1.1Sfa/Selenos⁺ involves: C57BL/6 * C57BL/10ScSn	abnormal respiratory quotient	J:266872
	abnormal skeletal muscle fiber type ratio	J:266872
	decreased body mass index	J:266872
	decreased lean body mass	J:266872
	increased carbon dioxide production	J:266872
	increased oxygen consumption	J:266872
	normal muscle phenotype	J:266872
Dmd^mdx/Dmd^mdx Snhg15^tm1Nju/Snhg15^tm1Nju involves: C57BL/6J * C57BL/10ScSn	normal growth/size/body region phenotype	J:291983
	impaired skeletal muscle regeneration	J:291983
	increased variability of skeletal muscle fiber size	J:291983
	normal muscle phenotype	J:291983
	skeletal muscle fibrosis	J:291983
Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn	abnormal muscle physiology	J:150572
	abnormal physical strength	J:150572
	decreased granulocyte number	J:150572
	decreased neutrophil cell number	J:150572
	decreased T cell number	J:150572
	increased regulatory T cell number	J:150572
	increased T cell number	J:150572
Dmd^mdx/Dmd^mdx Tg(ACTA1-SSPN)3.0Rcros/0 involves: C57BL/10ScSn	abnormal sarcolemma morphology	J:185346
	centrally nucleated skeletal muscle fibers	J:185346
	dystrophic muscle	J:185346
Dmd^mdx/Dmd^mdx Utrn^tm1Jrs/Utrn^tm1Jrs involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn	abnormal gait	J:42389
	abnormal limb morphology	J:42389, J:59675
	abnormal muscle physiology	J:42389
	abnormal muscle relaxation	J:42389
	abnormal neuromuscular synapse morphology	J:42389, J:60776
	cardiomyopathy	J:42389, J:59675
	decreased body size	J:42389
	dystrophic muscle	J:42389, J:59675
	kyphosis	J:42389, J:59675
	muscle degeneration	J:42389
	muscle weakness	J:42389
	myocardium necrosis	J:42389
	postnatal growth retardation	J:42389, J:59675
	premature death	J:42389, J:59675
	skeletal muscle interstitial fibrosis	J:42389
	skeletal muscle necrosis	J:42389
Dmd^mdx/Dmd^mdx Utrn^tm1Ked/Utrn^tm1Ked involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn * DBA	abnormal breathing pattern	J:42388
	abnormal gait	J:42388
	abnormal hindlimb morphology	J:42388
	abnormal neuromuscular synapse morphology	J:42388
	abnormal posture	J:42388
	abnormal skeletal muscle fiber morphology	J:42388
	abnormal skeletal muscle fiber size	J:42388
	centrally nucleated skeletal muscle fibers	J:42388
	decreased locomotor activity	J:42388
	dystrophic muscle	J:42388
	kyphosis	J:42388
	premature death	J:42388
	progressive muscle weakness	J:42388
	skeletal muscle interstitial fibrosis	J:42388
	skeletal muscle necrosis	J:42388
	weight loss	J:42388
Dmd^mdx/Y Dtna^tm1Jrs/Dtna^tm1Jrs involves: 129X1/SvJ * C57BL/10ScSn	abnormal neuromuscular synapse morphology	J:60776
	cardiomyopathy	J:59675
	dystrophic muscle	J:59675
	premature death	J:59675
Dmd^mdx/Y Dtna^tm1Jrs/Dtna^tm1Jrs Utrn^tm1Jrs/Utrn^tm1Jrs involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn	abnormal limb morphology	J:59675
	abnormal neuromuscular synapse morphology	J:60776
	cardiomyopathy	J:59675
	dystrophic muscle	J:59675
	kyphosis	J:59675
	postnatal growth retardation	J:59675
	postnatal lethality, incomplete penetrance	J:59675
	premature death	J:59675
	skeletal muscle necrosis	J:59675
Dmd^mdx/? Fgf2^tm1Zllr/Fgf2^tm1Zllr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn	dystrophic muscle	J:85088
Dmd^mdx/? Fgf2^tm1Zllr/Fgf2^tm1Zllr Fgf6^tm1Thbr/Fgf6^tm1Thbr involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn	abnormal muscle physiology	J:85088
	abnormal skeletal muscle fiber morphology	J:85088
	abnormal skeletal muscle morphology	J:85088
	abnormal spine curvature	J:85088
	decreased satellite cell number	J:85088
	dystrophic muscle	J:85088
	increased variability of skeletal muscle fiber size	J:85088
	normal muscle phenotype	J:85088
	skeletal muscle fiber necrosis	J:85088
Dmd^mdx/? Fgf6^tm1Thbr/Fgf6^tm1Thbr involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn	abnormal diaphragm morphology	J:42574
	abnormal epaxial muscle morphology	J:42574
	abnormal hypaxial muscle morphology	J:42574
	abnormal spine curvature	J:42574
	dystrophic muscle	J:85088
	normal muscle phenotype	J:42574
	myopathy	J:42574
Dmd^mdx/Y Foxk1^tm1Djg/Foxk1^tm1Djg involves: 129S4/SvJae * C57BL/10ScSn	decreased locomotor activity	J:62225
	postnatal lethality, incomplete penetrance	J:62225
	premature death	J:62225
	skeletal muscle fibrosis	J:62225
	skeletal muscle necrosis	J:62225
	weakness	J:62225
Dmd^mdx/Y Foxn1^nu/Foxn1^nu involves: C57BL/10ScSn	abnormal muscle morphology	J:95776
	decreased skeletal muscle fiber size	J:95776
	increased skeletal muscle fiber size	J:95776
Dmd^mdx/Y Mirc37^tm1Boet/Mirc37^tm1Boet involves: C57BL/10ScSn	dystrophic muscle	J:241493
	increased creatine kinase activity	J:241493
Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae involves: 129S4/SvJae * C57BL/10ScSn	abnormal heart ventricle morphology	J:52248
	cardiac fibrosis	J:52248
	cardiac interstitial fibrosis	J:52248
	dilated cardiomyopathy	J:52248
	increased heart weight	J:52248
	increased myocardial fiber size	J:52248
	myocardium necrosis	J:52248
	premature death	J:52248
Dmd^mdx/Y Nos1^tm1Plh/Nos1^tm1Plh involves: 129S4/SvJae * C57BL/10ScSn	abnormal circulating pyruvate kinase level	J:48851
	dystrophic muscle	J:48851
Dmd^mdx/Y Spp1^tm1Blh/Spp1^tm1Blh involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn	abnormal muscle physiology	J:150572
	abnormal physical strength	J:150572
	decreased granulocyte number	J:150572
	decreased neutrophil cell number	J:150572
	decreased T cell number	J:150572
	increased regulatory T cell number	J:150572
	increased T cell number	J:150572
Dmd^mdx/Y Terc^tm1Rdp/Terc⁺ involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL	abnormal diaphragm morphology	J:167294
	abnormal muscle physiology	J:167294
	centrally nucleated skeletal muscle fibers	J:167294
	increased circulating creatine kinase level	J:167294
Dmd^mdx/Y Terc^tm1Rdp/Terc^tm1Rdp involves: 129/Sv * C57BL/6J * C57BL/10ScSn * SJL	abnormal diaphragm morphology	J:167294
	abnormal muscle electrophysiology	J:167294
	abnormal muscle physiology	J:167294
	abnormal skeletal muscle morphology	J:167294
	calcified muscle	J:167294
	centrally nucleated skeletal muscle fibers	J:167294
	chromosomal instability	J:167294
	decreased satellite cell number	J:167294
	decreased telomere length	J:167294
	dystrophic muscle	J:167294
	impaired exercise endurance	J:167294
	increased circulating creatine kinase level	J:167294
	increased variability of skeletal muscle fiber size	J:167294
	kyphosis	J:167294
	muscle weakness	J:167294
	muscular atrophy	J:167294
	myositis	J:167294
	premature death	J:167294
	respiratory failure	J:167294
	skeletal muscle degeneration	J:167294
	skeletal muscle fibrosis	J:167294
	skeletal muscle necrosis	J:167294
Dmd^mdx/Y Tg(DMD)#Spc/0 involves: 129P2/OlaHsd C57BL/10ScSn * DBA/2	abnormal calcium level	J:280218
	dystrophic muscle	J:280218
	myositis	J:280218
	skeletal muscle fibrosis	J:280218
Dmd^mdx/Y Utrn^tm1Jrs/Utrn⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn	diaphragmitis	J:140282
	myositis	J:140282
	skeletal muscle endomysial fibrosis	J:140282
Dmd^tm1.1Know/Dmd^tm1.1Know A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ Tg(Myh6-2A)#Know/0 involves: BALB/c C3H * C57BL/6 * FVB/N	abnormal heart echocardiography feature	J:207775
	cardiac fibrosis	J:207775
	cardiomyopathy	J:207775
	decreased susceptibility to injury	J:207775
	increased cardiac muscle contractility	J:207775

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