F2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

F2
coagulation factor II
MGI:88380

37 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\F2^{tm1b(EUCOMM)Hmgu}/\F2⁺ C57BL/6N-F2^{tm1b(EUCOMM)Hmgu}/H	decreased bone mineral content	J:211773
	decreased exploration in new environment	J:211773
	decreased lean body mass	J:211773
	decreased mean corpuscular volume	J:211773
	increased circulating fructosamine level	J:211773
	increased circulating serum albumin level	J:211773
	increased total body fat amount	J:211773
	tremors	J:211773
\F2^{tm1b(EUCOMM)Hmgu}/\F2^{tm1b(EUCOMM)Hmgu} C57BL/6N-F2^{tm1b(EUCOMM)Hmgu}/H	preweaning lethality, incomplete penetrance	J:211773
\F2^tm1Jes/\F2^tm1Jes involves: 129P2/OlaHsd * C57BL/6J	abnormal vitelline vasculature morphology	J:48274
	embryonic lethality, incomplete penetrance	J:48274
	hemorrhage	J:48274
	intracranial hemorrhage	J:48274
	lethality throughout fetal growth and development, incomplete penetrance	J:48274
	lethality, incomplete penetrance	J:48274
	neonatal lethality, complete penetrance	J:48274
	pallor	J:48274
\F2^tm1Sjd/\F2⁺ involves: 129P2/OlaHsd	normal homeostasis/metabolism phenotype	J:174629
\F2^tm1Sjd/\F2^tm1Sjd involves: 129P2/OlaHsd * Black Swiss	abnormal visceral yolk sac morphology	J:48273
	decreased embryo size	J:48273
	distended pericardium	J:48273
	embryo tissue necrosis	J:48273
	embryonic growth arrest	J:48273
	embryonic lethality during organogenesis, incomplete penetrance	J:48273
	hemopericardium	J:48273
	hemorrhage	J:48273
	impaired blood coagulation	J:48273
	intestinal hemorrhage	J:48273
	neonatal lethality, complete penetrance	J:48273
	pale yolk sac	J:48273
	postnatal lethality, complete penetrance	J:48273
	purpura	J:48273
\F2^tm2Jld/\F2⁺ B6.129P2-F2^tm2Jld	abnormal circulating protein level	J:174629
	decreased susceptibility to endotoxin shock	J:174629
	decreased susceptibility to induced thrombosis	J:174629
	increased bleeding time	J:174629
\F2^tm2Jld/\F2⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA/2J	decreased susceptibility to induced arthritis	J:174629
\F2^tm2Jld/\F2^tm2Jld B6.129P2-F2^tm2Jld	internal hemorrhage	J:174629
	postnatal lethality, complete penetrance	J:174629
	subcutaneous hemorrhage	J:174629

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24