Cd40 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cd40
CD40 antigen
MGI:88336

32 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd40^m1Btlr/Cd40^m1Btlr C57BL/6J-Cd40^m1Btlr	impaired humoral immune response	J:221482
Cd40^m2Btlr/Cd40^m2Btlr C57BL/6J-Cd40^m2Btlr	abnormal humoral immune response	J:254828
Cd40^m2Btlr/Cd40^m2Btlr C57BL/6J-Cd40^m2Btlr	decreased IgG level	J:254828
Cd40^tm1Arah/Cd40^tm1Arah B6.129S1-Cd40^tm1Arah	abnormal immunoglobulin level	J:120512
	abnormal response to transplant	J:120512
	absent spleen germinal center	J:120512
	decreased IgE level	J:120512
	decreased IgG1 level	J:120512
	decreased IgG2b level	J:120512
	decreased IgG level	J:120512
	decreased IgM level	J:120512
	increased IgG3 level	J:120512
	increased IgM level	J:120512
Cd40^tm1Geha/Cd40^tm1Geha involves: 129S4/SvJae * C57BL/6	abnormal lymph node germinal center morphology	J:82298
	decreased IgA level	J:82298
	decreased IgG1 level	J:82298
	decreased IgG2a level	J:82298
	decreased IgG2b level	J:82298
	decreased spleen germinal center number	J:82298
	decreased spleen germinal center size	J:82298
Cd40^tm1Kik/Cd40^tm1Kik B6.129P2-Cd40^tm1Kik/J	abnormal dendritic cell physiology	J:86998
	decreased bone mineral density	J:145330
	decreased cerebral infarct size	J:108988
	decreased compact bone mass	J:145330
	decreased platelet aggregation	J:108988
	decreased trabecular bone mass	J:145330
	normal hematopoietic system phenotype	J:75152
	increased susceptibility to bacterial infection	J:86998
Cd40^tm1Kik/Cd40^tm1Kik involves: 129P2/OlaHsd	absent germinal center B cells	J:190943
	decreased B cell number	J:190943
	normal immune system phenotype	J:173115
Cd40^tm1Kik/Cd40^tm1Kik involves: 129P2/OlaHsd * C57BL/6	abnormal humoral immune response	J:25007
	absent spleen germinal center	J:25007
	decreased IgA level	J:25007
	decreased IgE level	J:25007
	decreased IgG1 level	J:25007
	decreased IgG2a level	J:25007
	decreased IgG2b level	J:25007
	decreased IgG3 level	J:25007
	decreased immunoglobulin level	J:25007
	decreased neutrophil cell number	J:25007
	decreased susceptibility to type II hypersensitivity reaction	J:61673
	normal immune system phenotype	J:25007

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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