Cd40^tm1Geha
Targeted Allele Detail

Summary

• Symbol: Cd40^tm1Geha
• Name: CD40 antigen; targeted mutation 1, Raif S Geha
• MGI ID: MGI:2655321
• Synonyms: CD40^-, CD40^M
• Gene: Cd40 Location: Chr2:164897535-164913574 bp, + strand Genetic Position: Chr2, 85.38 cM
• Alliance: Cd40^tm1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82369
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 7, 8, and 9 with a neomycin resistance cassette via homologous recombination. (J:82369)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd40 Mutation: 48 strains or lines available

References

• Original: J:82369 Castigli E, et al., CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12135-9
• All: 18 reference(s)