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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Cd4
CD4 antigen
MGI:88335
35 phenotypes from 16 alleles in 20 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Cd4del/Cd4del
C57BR/cdJ-Cd4del
abnormal immune system organ morphology J:46692
abnormal lymph node T cell domain morphology J:46692
abnormal spleen morphology J:46692
absent CD4-positive, alpha beta T cells J:46692
decreased IgG level J:46692
decreased IgM level J:46692
decreased immunoglobulin level J:46692
increased CD8-positive, alpha-beta T cell number J:46692
Cd4m1Btlr/Cd4m1Btlr
C57BL/6J-Cd4m1Btlr
absent CD4-positive, alpha beta T cells J:212900
impaired humoral immune response J:212900
Cd4maat/Cd4maat
C57BL/6JAnu-Cd4maat/Apb
abnormal CD4-positive, alpha beta T cell morphology J:104190
abnormal double-positive T cell morphology J:104190
decreased CD4-positive, alpha beta T cell number J:104190
increased CD8-positive, alpha-beta T cell number J:104190
Cd4sesh/Cd4sesh
C57BL/6JAnu-Cd4sesh/Apb
abnormal CD4-positive, alpha beta T cell morphology J:104190
abnormal double-positive T cell morphology J:104190
decreased T cell number J:104190
Cd4thth/Cd4thth
C57BL/6JSfdAnu-Cd4thth
absent CD4-positive, alpha beta T cells J:104190
Cd4tm1.1Yzo/Cd4tm1.1Yzo
involves: 129P2/OlaHsd
abnormal T cell differentiation J:130559
increased CD4-positive, alpha beta T cell number J:130559
increased double-positive T cell number J:130559
Cd4tm1Jrp/Cd4tm1Jrp
either: B6.129S2-Cd4tm1Jrp or B10.Cg-Cd4tm1Jrp
abnormal T cell differentiation J:45168
decreased CD4-positive, alpha beta T cell number J:45168
decreased double-positive T cell number J:45168
increased CD8-positive, alpha-beta T cell number J:45168
Cd4tm1Knw/Cd4tm1Knw
B6.129S-Cd4tm1Knw/J
decreased CD4-positive, alpha beta T cell number J:87828
increased CD8-positive, alpha-beta T cell number J:87828
increased susceptibility to parasitic infection J:87828
Cd4tm1Knw/Cd4tm1Knw
NOD.Cg-Cd4tm1Knw
decreased susceptibility to autoimmune diabetes J:93553
Cd4tm1Litt/Cd4tm1Litt
involves: 129S2/SvPas
abnormal CD4-positive, alpha-beta T cell physiology J:50435
absent CD4-positive, alpha beta T cells J:50435
decreased CD4-positive, alpha beta T cell number J:158962
decreased T cell proliferation J:50435
increased CD8-positive, alpha-beta T cell number J:50435, J:158962
Cd4tm1Litt/Cd4tm1Nik
Tg(Lck-cre)3778Nik/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
abnormal CD4-positive, alpha-beta T cell physiology J:73479
abnormal interleukin-4 secretion J:73479
abnormal T-helper 2 physiology J:73479
decreased T cell proliferation J:73479
Cd4tm1Litt/Cd4tm1Nik
Tg(Lck-cre)3785Nik/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
abnormal CD4-positive, alpha-beta T cell physiology J:73479
decreased CD4-positive, alpha beta T cell number J:73479
increased CD8-positive, alpha-beta T cell number J:73479
increased T cell apoptosis J:73479
increased T cell proliferation J:73479
Cd4tm1Litt/Cd4tm1Nik
Tg(Lck-icre)3779Nik/0
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
abnormal CD4-positive, alpha-beta T cell physiology J:73479
decreased T cell proliferation J:73479
Cd4tm1Mak/Cd4tm1Mak
B6.129S2-Cd4tm1Mak/J
abnormal bile salt level J:133047
absent plasma cells J:133047
normal immune system phenotype J:133047
Cd4tm1Mak/Cd4tm1Mak
involves: 129S2/SvPas
normal immune system phenotype J:110749
Cd4tm1Mak/Cd4tm1Mak
involves: 129S2/SvPas * C57BL/6 * DBA/2
abnormal CD4-positive, alpha-beta T cell physiology J:68957
demyelination J:92227
increased CD8-positive, alpha-beta T cell number J:68957
increased susceptibility to viral infection J:92227
Cd4tm1Mak/Cd4tm1Mak
PL.129S2(B6)-Cd4tm1Mak/Rdgz
brain inflammation J:92227
demyelination J:92227
increased susceptibility to viral infection J:92227
Cd4tm1Mak/Cd4tm1Mak
SJL.129S2(B6)-Cd4tm1Mak/Rdgz
brain inflammation J:92227
demyelination J:92227
increased susceptibility to viral infection J:92227
Cd4tm1Nik/Cd4tm1Nik
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ
abnormal regulatory T cell physiology J:152472
Cd4tm1Yzo/Cd4tm1Yzo
involves: 129P2/OlaHsd
no abnormal phenotype detected J:130559
Cd4tm1Yzo/Cd4tm1Yzo
Tg(Cd4-cre)1Cwi/?
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
abnormal T cell differentiation J:130559
increased double-positive T cell number J:130559
Cd4tm1Yzo/Cd4tm1Yzo
Tg(Cd8a-cre,GFP)1Yzo/?
involves: 129P2/OlaHsd
increased double-positive T cell number J:130559
Cd4tm2Litt/Cd4tm2Litt
involves: 129P2/OlaHsd
abnormal CD8-positive, alpha beta T cell morphology J:80690
Cd4tm3.1Litt/Cd4tm3.1Litt
involves: 129P2/OlaHsd * FVB/N
normal immune system phenotype J:158962
Cd4tm3.1Litt/Cd4tm3.1Litt
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
abnormal T cell differentiation J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha beta T cell number J:158962
decreased double-positive T cell number J:158962
increased CD8-positive, alpha-beta T cell number J:158962
Cd4tm3.1Litt/Cd4tm4.1Litt
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
normal immune system phenotype J:158962
Cd4tm3.1Litt/Cd4tm4.1Litt
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
abnormal T cell differentiation J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha beta T cell number J:158962
increased CD8-positive, alpha-beta T cell number J:158962
Cd4tm3.2Litt/Cd4tm3.2Litt
involves: 129P2/OlaHsd * FVB/N
abnormal CD4-positive, alpha beta T cell morphology J:158962
abnormal double-positive T cell morphology J:158962
abnormal T cell differentiation J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha beta T cell number J:158962
decreased double-positive T cell number J:158962
normal immune system phenotype J:158962
increased CD8-positive, alpha-beta T cell number J:158962
Cd4tm3.2Litt/Cd4tm4.1Litt
involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N
abnormal T cell differentiation J:158962
abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha beta T cell number J:158962
increased CD8-positive, alpha-beta T cell number J:158962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory