About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ccnd1
cyclin D1
MGI:88313
53 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Ccnd1tm1Dsn/Ccnd1tm1Dsn
involves: C57BL/6J 		increased intestinal adenoma incidence J:78500
Ccnd1tm1Dsn/Ccnd1tm1Dsn
Ccnd2tm1Wbg/Ccnd2tm1Wbg
Ccnd3tm1Pisc/Ccnd3tm1Pisc
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal common myeloid progenitor cell morphology J:92563
abnormal definitive hematopoiesis J:92563
abnormal hematopoietic stem cell morphology J:92563
abnormal interventricular septum morphology J:92563
abnormal lymphopoiesis J:92563
anemia J:92563
decreased erythrocyte cell number J:92563
decreased hematopoietic stem cell number J:92563
hydrops fetalis J:92563
lethality throughout fetal growth and development, complete penetrance J:92563
thin ventricular wall J:92563
Ccnd1tm1Dsn/Ccnd1tm1Dsn
Cdkn1btm1Mlf/Cdkn1btm1Mlf
involves: 129 * C57BL/6 		abnormal corpus luteum morphology J:66707
abnormal reflex J:66707
normal craniofacial phenotype J:66707
disorganized retina layers J:66707
normal endocrine/exocrine gland phenotype J:66707
enlarged spleen J:66707
enlarged testis J:66707
enlarged thymus J:66707
female infertility J:66707
increased body weight J:66707
increased pituitary adenoma incidence J:66707
normal mortality/aging J:66707
thymus hyperplasia J:66707
Ccnd1tm1Phin/Ccnd1tm1Phin
Ccnd2tm1Wbg/Ccnd2tm1Wbg
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		abnormal cerebellum development J:105045
Ccnd1tm1Phin/Ccnd1tm1Phin
Tg(MMTV-Erbb2)NK1Mul/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		decreased mammary gland tumor incidence J:105045
Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
involves: 129S2/SvPas * FVB/N 		increased mammary gland tumor incidence J:178842
Ccnd1tm1Wbg/Ccnd1+
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
involves: 129S2/SvPas * FVB/N 		increased mammary gland tumor incidence J:178842
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Ccnd2tm1Wbg/Ccnd2tm1Wbg
Not Specified 		abnormal cerebellar granule layer morphology J:80994
absent Purkinje cell layer J:80994
ectopic Purkinje cell J:80994
impaired coordination J:80994
postnatal lethality J:80994
reduced cerebellar foliation J:80994
retina hypoplasia J:80994
small cerebellum J:80994
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Not Specified 		abnormal suckling behavior J:80994
aspiration J:80994
decreased body size J:80994
neonatal lethality, incomplete penetrance J:80994
retina hypoplasia J:80994
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Smarcb1tm1Gvk/Smarcb1+
involves: 129/Sv * 129S2/SvPas * C57BL/6J * SJL/J 		abnormal eye development J:101185
abnormal nervous system development J:101185
decreased body size J:101185
decreased tumor incidence J:101185
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTV-tTA)25755Kuw/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
involves: 129S2/SvPas * FVB/N 		normal endocrine/exocrine gland phenotype J:178842
lactation failure J:178842
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTV-tTA)25755Kuw/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
involves: 129S2/SvPas * FVB/N 		normal endocrine/exocrine gland phenotype J:178842
lactation failure J:178842
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
involves: 129S2/SvPas * FVB/N 		abnormal spermatogenesis J:178842
male infertility J:178842
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)10897Kuw/0
involves: 129S2/SvPas * FVB/N 		increased mammary gland tumor incidence J:178842
increased tumor latency J:178842
Ccnd1tm1Wbg/Ccnd1tm1Wbg
Tg(MMTVneu)202Mul/0
Tg(tetO-Ccnd1*T286A,-luc)11233Kuw/0
involves: 129S2/SvPas * FVB/N 		increased mammary gland tumor incidence J:178842
increased tumor latency J:178842
Ccnd1tm1Wbg/Ccnd1tm5.1Pisc
Tg(CAG-cre/Esr1*)5Amc/0
Tg(MMTV-Erbb2)NK1Mul/0
involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N 		decreased tumor growth/size J:192032
Ccnd1tm2(Ccnd2)Pisc/Ccnd1tm2(Ccnd2)Pisc
involves: 129S4/SvJae 		abnormal eye electrophysiology J:95994
decreased body weight J:95994
limb grasping J:95994
normal reproductive system phenotype J:95994
Ccnd1tm4Pisc/Ccnd1tm4Pisc
Tg(MMTV-Erbb2)NK1Mul/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		increased mammary adenocarcinoma incidence J:156591
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory