Tg(tetO-Ccnd1*T286A,-luc)10897Kuw
Transgene Detail

Summary

• Symbol: Tg(tetO-Ccnd1*T286A,-luc)10897Kuw
• Name: transgene insertion 10897, Kay-Uwe Wagner
• MGI ID: MGI:5300556
• Synonyms: TetO-D1
• Transgene: Tg(tetO-Ccnd1*T286A,-luc)10897Kuw Location: unknown
• Alliance: Tg(tetO-Ccnd1*T286A,-luc)10897Kuw page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The tetracycline operator drives inducible expression of the FLAG-tagged mouse Ccnd1 cDNA with a point mutation that results in the amino acid substitution of alanine for threonine at position 286 (T286A) and an IRES-luciferase. Two lines were generated (10897 and 11233). (J:178842)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-Ccnd1*T286A,-luc)10897Kuw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:178842 Zhang Q, et al., Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression. Cancer Res. 2011 Dec 15;71(24):7513-24
• All: 2 reference(s)