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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atf4
activating transcription factor 4
MGI:88096
73 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atf4tm1(KOMP)Mbp/Atf4+
C57BL/6NCrl-Atf4tm1(KOMP)Mbp/MbpMmucd 		abnormal heart morphology J:211773
decreased monocyte cell number J:211773
enlarged heart J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased mean corpuscular hemoglobin J:211773
Atf4tm1(KOMP)Mbp/Atf4tm1(KOMP)Mbp
C57BL/6NCrl-Atf4tm1(KOMP)Mbp/MbpMmucd 		preweaning lethality, complete penetrance J:211773
Atf4tm1.1Cmad/Atf4tm1.1Cmad
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6 * FVB 		decreased susceptibility to induced muscular atrophy J:206503
normal muscle phenotype J:206503
Atf4tm1.1Cmad/Atf4tm1.1Cmad
Tg(Myh11-icre/ERT2)1Soff/?
D2.Cg-Atf4tm1.1Cmad Tg(Myh11-icre/ERT2)1Soff 		abnormal aorta morphology J:237331
abnormal calcium ion homeostasis J:237331
normal homeostasis/metabolism phenotype J:237331
Atf4tm1Aki/Atf4tm1Aki
involves: 129P2/OlaHsd 		abnormal lens fiber morphology J:56007
abnormal vas deferens morphology J:96728
increased lens epithelium apoptosis J:56007
microphthalmia J:56007
postnatal lethality, incomplete penetrance J:56007
reduced male fertility J:96728
Atf4tm1Aki/Atf4tm1Aki
Tg(Cryaa-Atf4)4Aki/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal lens fiber morphology J:56007
Atf4tm1Jml/Atf4tm1Jml
involves: 129X1/SvJ 		abnormal ciliary body morphology J:62578
abnormal iris morphology J:62578
aphakia J:62578
decreased body size J:62578
decreased fetal size J:62578
eyelids fail to open J:62578
microphthalmia J:62578
perinatal lethality, incomplete penetrance J:62578
Atf4tm1Kry/Atf4tm1Kry
Tg(Col1a1-cre)1Kry/0
involves: C57BL/6J * FVB 		abnormal glucose homeostasis J:152695
abnormal glycogen homeostasis J:152695
decreased body weight J:152695
decreased circulating glucose level J:152695
normal homeostasis/metabolism phenotype J:152695
impaired gluconeogenesis J:152695
improved glucose tolerance J:152695
increased insulin secretion J:152695
increased insulin sensitivity J:152695
Atf4tm1Tow/Atf4tm1Tow
either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J * NIH Black Swiss) or (involves: 129P2/OlaHsd * C57BL/6J * NIH Black Swiss) 		decreased circulating glucose level J:152695
decreased total fat pad weight J:152695
impaired gluconeogenesis J:152695
improved glucose tolerance J:152695
increased circulating insulin level J:152695
increased insulin secretion J:152695
increased insulin sensitivity J:152695
increased pancreatic beta cell mass J:152695
increased pancreatic beta cell proliferation J:152695
Atf4tm1Tow/Atf4tm1Tow
either: (involves: 129P2/OlaHsd * NIH Black Swiss) or (involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss) 		abnormal bone mineralization J:89403
abnormal bone ossification J:89403
abnormal bone trabecula morphology J:89403
abnormal clavicle morphology J:89403
abnormal frontal bone morphology J:89403
abnormal neurocranium morphology J:89403
abnormal osteoblast differentiation J:129974
abnormal pancreas morphology J:129974
abnormal pancreatic acinar cell morphology J:129974
abnormal pancreatic acinar cell zymogen granule morphology J:129974
abnormal pancreatic acinus morphology J:129974
abnormal parietal bone morphology J:89403
decreased bone mineral density J:89403
exocrine pancreas hypoplasia J:89403
large fontanelles J:89403
Atf4tm1Tow/Atf4tm1Tow
involves: 129S1/Sv * 129X1/SvJ * NIH Black Swiss 		absent common myeloid progenitor cells J:74479
anemia J:74479
decreased body length J:74479
decreased body weight J:74479
decreased cell proliferation J:74479
decreased hematocrit J:74479
decreased hepatocyte number J:74479
delayed hair appearance J:74479
female infertility J:74479
impaired hematopoiesis J:74479
male infertility J:74479
microphthalmia J:74479
pale liver J:74479
perinatal lethality, incomplete penetrance J:74479
postnatal growth retardation J:74479
postnatal lethality, incomplete penetrance J:74479
reduced male fertility J:74479
ruffled hair J:74479
Tg(CMV-Atf4)1Kry/0
involves: C57BL/6J 		normal endocrine/exocrine gland phenotype J:152695
normal homeostasis/metabolism phenotype J:152695
Tg(Col1a1-Atf4)1Kry/0
involves: FVB 		abnormal circulating glucose level J:152695
decreased circulating insulin level J:152695
decreased insulin secretion J:152695
decreased pancreatic beta cell proliferation J:152695
normal homeostasis/metabolism phenotype J:152695
impaired glucose tolerance J:152695
increased circulating glucose level J:152695
increased physiological sensitivity to xenobiotic J:152695
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory