About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Grk2
G protein-coupled receptor kinase 2
MGI:87940
39 phenotypes from 3 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Grk2tm1.1Gwd/Grk2tm1.1Gwd
involves: 129S4/SvJaeSor * FVB/N
abnormal heart tube morphology J:126501
embryonic growth arrest J:126501
embryonic growth retardation J:126501
embryonic lethality during organogenesis, complete penetrance J:126501
pericardial edema J:126501
Grk2tm1Gwd/Grk2tm1Gwd
involves: 129S4/SvJaeSor
no abnormal phenotype detected J:126501
Grk2tm1Gwd/Grk2tm1Gwd
Cd79atm1(cre)Reth/Cd79a+
involves: 129 * BALB/c * C57BL/6
abnormal B cell physiology J:176118
decreased B cell number J:176118
increased B cell number J:176118
increased CD4-positive, alpha beta T cell number J:176118
increased CD8-positive, alpha-beta T cell number J:176118
increased follicular B cell number J:176118
increased marginal zone B cell number J:176118
Grk2tm1Gwd/Grk2tm1Gwd
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
normal cardiovascular system phenotype J:126501
decreased physiological sensitivity to xenobiotic J:126501
increased physiological sensitivity to xenobiotic J:126501
normal mortality/aging J:126501
Grk2tm1Gwd/Grk2tm1Mca
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2
abnormal T cell physiology J:176118
decreased CD4-positive, alpha beta T cell number J:176118
decreased CD8-positive, alpha-beta T cell number J:176118
decreased T cell number J:176118
impaired leukocyte tethering or rolling J:176118
increased B cell number J:176118
Grk2tm1Mca/Grk2tm1Mca
involves: 129
abnormal interventricular septum morphology J:36567
abnormal myocardial trabeculae morphology J:36567
atrium hypoplasia J:36567
decreased embryo size J:36567
decreased ventricle muscle contractility J:36567
dilated heart right atrium J:36567
disorganized myocardium J:36567
embryonic lethality during organogenesis, incomplete penetrance J:36567
fetal growth retardation J:36567
heart hypoplasia J:36567
lethality throughout fetal growth and development, complete penetrance J:36567
pallor J:36567
thin myocardium J:36567
thin myocardium compact layer J:36567
thin ventricular wall J:36567
trabecula carnea hypoplasia J:36567
ventricular hypoplasia J:36567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/23/2021
MGI 6.16
The Jackson Laboratory