Acr Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Acr
acrosin prepropeptide
MGI:87884

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Acr^tm1Wen/Acr^tm1Wen H1f1^tm1Drab/H1f1^tm1Drab Smcp^tm1Wen/Smcp^tm1Wen involves: 129/Sv * C57BL/6J * CD-1	asthenozoospermia	J:98301
	impaired binding of sperm to zona pellucida	J:98301
	impaired fertilization	J:98301
	reduced male fertility	J:98301
Acr^tm1Wen/Acr^tm1Wen H1f1^tm1Drab/H1f1^tm1Drab Tnp2^tm1Wen/Tnp2^tm1Wen involves: 129 * C57BL/6J * CD-1b	no abnormal phenotype detected	J:86670
Acr^tm1Wen/Acr^tm1Wen H1f6^tm1Ais/H1f6^tm1Ais Tnp2^tm1Wen/Tnp2^tm1Wen involves: 129/Sv * C57BL/6J * CD-1 * SJL	no abnormal phenotype detected	J:86670
Acr^tm1Wen/Acr^tm1Wen H1f6^tm1Drab/H1f6^tm1Drab Smcp^tm1Wen/Smcp^tm1Wen involves: 129/Sv * C57BL/6J * CD-1	abnormal sperm head morphology	J:98301
	asthenozoospermia	J:98301
	impaired binding of sperm to zona pellucida	J:98301
	impaired fertilization	J:98301
	impaired sperm migration in female genital tract	J:98301
	reduced male fertility	J:98301
Acr^tm1Wen/Acr^tm1Wen Smcp^tm1Wen/Smcp^tm1Wen Tnp2^tm1Wen/Tnp2^tm1Wen involves: 129/Sv * C57BL/6J * CD-1	asthenozoospermia	J:98301
	impaired binding of sperm to zona pellucida	J:98301
	impaired sperm migration in female genital tract	J:98301
	male infertility	J:98301
Phf7^em2Osb/Phf7^em2Osb Tg(CAG-EGFP,Acr-EGFP)2Osb/0 involves: 129S2/SvPas * C57BL/6NSlc	abnormal sperm nucleus morphology	J:298823
	asthenozoospermia	J:298823
	decreased fertilization frequency	J:298823
	male infertility	J:298823
	oligozoospermia	J:298823
	teratozoospermia	J:298823
Tex101^tm1Osb/Tex101^tm1Osb Tg(CAG-EGFP,Acr-EGFP)2Osb/Tg(CAG-EGFP,Acr-EGFP)2Osb involves: C57BL/6NSlc	abnormal acrosome reaction	J:197323
	abnormal hyperactivated sperm motility	J:197323
	normal behavior/neurological phenotype	J:197323
	impaired binding of sperm to zona pellucida	J:197323
	impaired sperm migration in female genital tract	J:197323
	male infertility	J:197323
	normal reproductive system phenotype	J:197323
Zfp541^em1Osb/Zfp541^em1Osb Tg(CAG-EGFP,Acr-EGFP)2Osb/0 involves: 129S2/SvPas * C57BL/6NSlc	abnormal male meiosis	J:306305
	abnormal spermatid morphology	J:306305
	abnormal synaptonemal complex	J:306305
	abnormal X-Y chromosome synapsis during male meiosis	J:306305
	arrest of male meiosis	J:306305
	increased primordial germ cell apoptosis	J:306305
	male infertility	J:306305

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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