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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Shank2
SH3 and multiple ankyrin repeat domains 2
MGI:2671987
32 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Shank2tm1.1Bcgen/Shank2tm1.1Bcgen
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
abnormal excitatory synapse morphology J:237188
abnormal miniature excitatory postsynaptic currents J:237188
impaired coordination J:237188
increased anxiety-related response J:237188
increased stereotypic behavior J:237188
Shank2tm1.1Tmb/Shank2+
B6.129-Shank2tm1.1Tmb
abnormal excitatory postsynaptic potential J:186719
hyperactivity J:186719
increased anxiety-related response J:186719
postnatal lethality, incomplete penetrance J:186719
Shank2tm1.1Tmb/Shank2tm1.1Tmb
B6.129-Shank2tm1.1Tmb
abnormal dendritic spine morphology J:186719
abnormal excitatory postsynaptic potential J:186719
abnormal miniature excitatory postsynaptic currents J:186719
abnormal motor capabilities/coordination/movement J:186719
abnormal response to novelty J:186719
abnormal sexual interaction J:186719
abnormal social investigation J:186719
abnormal vocalization J:186719
decreased body weight J:186719
enhanced long term potentiation J:186719
hyperactivity J:186719
impaired righting response J:186719
improved righting response J:186719
increased anxiety-related response J:186719
increased grooming behavior J:186719
increased stereotypic behavior J:186719
limb grasping J:186719
postnatal lethality, incomplete penetrance J:186719
Shank2tm1Mgle/Shank2+
B6.129S4-Shank2tm1Mgle
normal behavior/neurological phenotype J:186718
hyperactivity J:186718
Shank2tm1Mgle/Shank2tm1Mgle
B6.129S4-Shank2tm1Mgle
abnormal cerebellar molecular layer J:237188
abnormal excitatory synapse morphology J:237188
abnormal learning/memory/conditioning J:186718
abnormal miniature excitatory postsynaptic currents J:237188
abnormal nervous system physiology J:186718
abnormal nest building behavior J:186718
abnormal pup retrieval J:186718
abnormal social investigation J:186718
abnormal spatial learning J:186718
abnormal voluntary movement J:186718
decreased vocalization J:186718
hyperactivity J:186718
impaired coordination J:237188
increased anxiety-related response J:186718, J:237188
increased grooming behavior J:186718
normal nervous system phenotype J:186718
reduced long term depression J:186718
reduced long term potentiation J:186718

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory