Shank2^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Shank2^tm1.1Bcgen
• Name: SH3 and multiple ankyrin repeat domains 2; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:5816912
• Synonyms: Shank2^fl
• Gene: Shank2 Location: Chr7:143555665-143978231 bp, + strand Genetic Position: Chr7, 88.45 cM
• Alliance: Shank2^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237188
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 6 and 7 were flanked by loxP sites. In addition, an EGFP gene and Neo selection cassette separated by a loxP site and flanked by FRT sites was inserted upstream of the floxed exons 6-7. Flp-mediated recombination removed the FRT-flanked EGFP and Neo selection cassette, leaving an FRT site and floxed exons 6-7. (J:237188)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank2 Mutation: 91 strains or lines available

References

• Original: J:237188 Ha S, et al., Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors. J Neurosci. 2016 Nov 30;36(48):12129-12143
• All: 3 reference(s)