Shank2^tm1.1Tmb
Targeted Allele Detail

Summary

• Symbol: Shank2^tm1.1Tmb
• Name: SH3 and multiple ankyrin repeat domains 2; targeted mutation 1.1, Tobias M Boeckers
• MGI ID: MGI:5435698
• Synonyms: Shank2^-
• Gene: Shank2 Location: Chr7:143555665-143978231 bp, + strand Genetic Position: Chr7, 88.45 cM
• Alliance: Shank2^tm1.1Tmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186719
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 7 via homologous recombination. Recombinase mediated recombination deleted exon 7 and the neo cassette. (J:186719)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank2 Mutation: 91 strains or lines available

References

• Original: J:186719 Schmeisser MJ, et al., Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Jun 14;486(7402):256-60
• All: 16 reference(s)