58 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aviltm2(cre)Fawa/Avil+ Pik3c3tm1Fawa/Pik3c3tm1Fawa involves: 129P2/OlaHsd	abnormal posture	J:160568
	abnormal proprioceptive neuron morphology	J:160568
	abnormal sensory neuron morphology	J:160568
	axon degeneration	J:160568
	decreased sensory neuron number	J:160568
	hindlimb paralysis	J:160568
	impaired coordination	J:160568
	increased neuron apoptosis	J:160568
	neurodegeneration	J:160568
	postnatal lethality, complete penetrance	J:160568
Pik3c3tm1.1Fawa/Pik3c3tm1.1Fawa involves: 129S4/SvJaeSor * C57BL/6J	abnormal embryonic epiblast morphology	J:169569
	abnormal visceral endoderm morphology	J:169569
	absent mesoderm	J:169569
	normal cellular phenotype	J:169569
	decreased cell proliferation	J:169569
	decreased embryo size	J:169569
	disorganized embryonic tissue	J:169569
	embryonic growth arrest	J:169569
	embryonic growth retardation	J:169569
	embryonic lethality between implantation and placentation, complete penetrance	J:169569
	failure of primitive streak formation	J:169569
	failure to gastrulate	J:169569
Pik3c3tm1.1Flv/Pik3c3tm1.1Flv Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * C57BL/6N * DBA/2	abnormal autophagy	J:184753
	abnormal T cell number	J:184753
	decreased CD4-positive, alpha-beta T cell number	J:184753
	decreased CD8-positive, alpha-beta T cell number	J:184753
Pik3c3tm1.1Flv/Pik3c3tm1.1Flv Tg(Cd8a-cre)1Itan/0 involves: C57BL/6 * C57BL/6N	abnormal CD4-positive, alpha beta T cell morphology	J:184753
	abnormal CD8-positive, alpha beta T cell morphology	J:184753
	abnormal mitochondrial morphology	J:184753
	abnormal mitochondrial physiology	J:184753
	decreased CD4-positive, alpha-beta T cell number	J:184753
	decreased CD8-positive, alpha-beta T cell number	J:184753
	decreased lymphocyte cell number	J:184753
	normal immune system phenotype	J:184753
	increased T cell apoptosis	J:184753
	oxidative stress	J:184753
Pik3c3tm1a(EUCOMM)Wtsi/Pik3c3+ C57BL/6N-Pik3c3tm1a(EUCOMM)Wtsi/Ics	decreased body weight	J:165965
	decreased circulating aspartate transaminase level	J:165965
	decreased grip strength	J:165965
Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi involves: C57BL/6N	abnormal autophagy	J:182628
	abnormal vacuole morphology	J:182628
	decreased cell proliferation	J:182628
Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ involves: C57BL/6 * C57BL/6N * DBA	abnormal liver morphology	J:182628
	decreased body size	J:182628
	decreased liver glycogen level	J:182628
	enlarged liver	J:182628
	hepatic steatosis	J:182628
	pale liver	J:182628
	premature death	J:182628
Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi Tg(Ckmm-cre)5Khn/0 involves: C57BL/6N * FVB/N	abnormal heart left ventricle morphology	J:182628
	abnormal heart morphology	J:182628
	congestive heart failure	J:182628
	decreased cardiac muscle contractility	J:182628
	enlarged heart	J:182628
	increased heart left ventricle weight	J:182628
	increased heart weight	J:182628
	premature death	J:182628
Pik3c3tm1Fawa/Pik3c3tm1Fawa Not Specified	no abnormal phenotype detected	J:160568
Pik3c3tm1Tssk/Pik3c3tm1Tssk Tg(Cryaa-cre)10Mlr/0 involves: FVB/N	abnormal lens fiber morphology	J:198392
	cataract	J:198392
	impaired autophagy	J:198392
	microphthalmia	J:198392
	small lens	J:198392