Pik3c3^tm1Tssk
Targeted Allele Detail

Summary

• Symbol: Pik3c3^tm1Tssk
• Name: phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1, Takehiko Sasaki
• MGI ID: MGI:5529808
• Synonyms: Pik3c3^flox
• Gene: Pik3c3 Location: Chr18:30405800-30481179 bp, + strand Genetic Position: Chr18, 17.41 cM
• Alliance: Pik3c3^tm1Tssk page

Cataracts and impaired differentiation of secondary lens fiber cells in Pik3c3^tm1Tssk/Pik3c3^tm1Tssk Tg(Cryaa-cre)10Mlr/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198392
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 20 and 21 were floxed. (J:198392)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c3 Mutation: 45 strains or lines available

References

• Original: J:198392 Morishita H, et al., Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem. 2013 Apr 19;288(16):11436-47
• All: 2 reference(s)